Biological materials are self-assembled with near-atomic precision in living cells, whereas
synthetic 3D structures generally lack such precision and controllability. Recently, DNA …

DNA origami has emerged as a powerful method to generate DNA nanostructures with
dynamic properties and nanoscale control. These nanostructures enable complex …

Secretory IgA has long been a divisive molecule. Some immunologists point to the mild
phenotype of IgA deficiency to justify ignoring it, while some consider its abundance and …

Vaccine efficacy can be increased by arraying immunogens in multivalent form on virus-like
nanoparticles to enhance B-cell activation. However, the effects of antigen copy number …

Multispecific antibodies have emerged as versatile therapeutic agents, and therefore,
approaches to optimize and streamline their design and assembly are needed. Here we …

Living systems achieve robust self-assembly across a wide range of length scales. In the
synthetic realm, nanofabrication strategies such as DNA origami have enabled robust self …

Obtaining efficient drug delivery to the brain remains the biggest challenge for the
development of therapeutics to treat diseases of the central nervous system. The main …

Standard cancer therapies sometimes fail to deliver chemotherapeutic drugs to tumor cells
in a safe and effective manner. Nanotechnology takes the lead in providing new therapeutic …

DNA, when folded into nanostructures with a specific shape, is capable of spacing and
arranging binding sites into a complex geometric pattern with nanometre precision. Here we …

First evidence of geometrical patterns and defined distances of biomolecules as
fundamental parameters to regulate receptor binding and cell signaling have emerged …