Tumor-associated macrophages (TAMs) are major innate immune cells that constitute up to
50% of the cell mass of human tumors. TAMs are highly heterogeneous cells that originate …

Despite the high long-term survival in localized prostate cancer, metastatic prostate cancer
remains largely incurable even after intensive multimodal therapy. The lethality of advanced …

The treatment of low-risk primary prostate cancer entails active surveillance only, while high-
risk disease requires multimodal treatment including surgery, radiation therapy, and …

Background Advanced prostate cancer remains one of the most common and deadly
cancers, despite advances in treatment options. Immunotherapy has provided little benefit to …

Chronic inflammation promotes the development of several types of solid cancers and might
contribute to prostate carcinogenesis. This hypothesis partly originates in the frequent …

Prostate cancer stem cells (PCSCs) play a critical role in prostate cancer progression and
metastasis, which remains an obstacle for successful prostate cancer treatment. Tumor …

Tumor-associated macrophages (TAMs) represent a major component of the tumor
microenvironment supporting tumorigenesis. TAMs re-education has been proposed as a …

Macrophages have been shown to demonstrate a high level of plasticity, with the ability to
undergo dynamic transition between M1 and M2 polarized phenotypes. We investigate long …

Background Immunotherapy has been less successful in treating prostate cancer than other
solid tumors. We sought to better understand the immune landscape in prostate cancer and …

Background Prostate cancer (PCa) is one of the most frequently diagnosed cancers in the
world. Emerging evidence suggests that inflammatory cells such as M2 macrophages and …