Nanotechnology-based ocular drug delivery systems: recent advances and future prospects

S Li, L Chen, Y Fu - Journal of Nanobiotechnology, 2023 - Springer
Ocular drug delivery has constantly challenged ophthalmologists and drug delivery
scientists due to various anatomical and physiological barriers. Static and dynamic ocular …

Developments in Emerging Topical Drug Delivery Systems for Ocular Disorders

S Mandal, P Vishvakarma… - Current Drug Research …, 2024 - benthamdirect.com
According to the current information, using nano gels in the eyes have therapeutic benefits.
Industry growth in the pharmaceutical and healthcare sectors has been filled by …

Recent progress of solid lipid nanoparticles and nanostructured lipid carriers as ocular drug delivery platforms

V Gugleva, V Andonova - Pharmaceuticals, 2023 - mdpi.com
Sufficient ocular bioavailability is often considered a challenge by the researchers, due to
the complex structure of the eye and its protective physiological mechanisms. In addition, the …

Challenges and strategies for ocular posterior diseases therapy via non-invasive advanced drug delivery

Q Qi, Y Wei, X Zhang, J Guan, S Mao - Journal of Controlled Release, 2023 - Elsevier
Posterior segment diseases, such as age-related macular degeneration (AMD) and diabetic
retinopathy (DR) are vital factor that seriously threatens human vision health and quality of …

Therapeutic applications of contact lens-based drug delivery systems in ophthalmic diseases

L Zhao, J Song, Y Du, C Ren, B Guo, H Bi - Drug Delivery, 2023 - Taylor & Francis
Traditional ophthalmic drugs, such as eye drops, gels and ointments, are accompanied by
many problems, including low bioavailability and potential drug side effects. Innovative …

Trans-corneal drug delivery strategies in the treatment of ocular diseases

L Li, F Jia, Y Wang, J Liu, Y Tian, X Sun, Y Lei… - Advanced Drug Delivery …, 2023 - Elsevier
The cornea is a remarkable tissue that possesses specialized structures designed to
safeguard the eye against foreign objects. However, its unique properties also make it …

Brain-derived neurotrophic factor-mediated neuroprotection in glaucoma: a review of current state of the art

L Lambuk, MA Mohd Lazaldin, S Ahmad… - Frontiers in …, 2022 - frontiersin.org
Retinal ganglion cells (RGCs) are neurons of the visual system that are responsible for
transmitting signals from the retina to the brain via the optic nerve. Glaucoma is an optic …

Recent advancements in nanomaterial-laden contact lenses for diagnosis and treatment of glaucoma, review and update

R Baghban, MR Talebnejad, A Meshksar… - Journal of …, 2023 - Springer
Despite the existence of numerous eye drops in the market, most of them are not sufficiently
effective because of quick clearance and the barriers within the eye. To increase the delivery …

Overcoming Treatment Challenges in Posterior Segment Diseases with Biodegradable Nano-Based Drug Delivery Systems

KY Wu, M Joly-Chevrier, D Akbar, SD Tran - Pharmaceutics, 2023 - mdpi.com
Posterior segment eye diseases present a challenge in treatment due to the complex
structures in the eye that serve as robust static and dynamic barriers, limiting the penetration …

Optimization of hyaluronan-enriched cubosomes for bromfenac delivery enhancing corneal permeation: characterization, ex vivo, and in vivo evaluation

NA Shoman, RM Gebreel, MA El-Nabarawi, A Attia - Drug Delivery, 2023 - Taylor & Francis
To design and evaluate hyaluronan-based cubosomes loaded with bromfenac sodium (BS)
for ocular application to enhance the corneal permeation and retention in pterygium and …