I. Introduction IN 1958, Lerner and co-workers (1) described the biological properties of the
first nonsteroidal antiestrogen MER25 (see Fig. 1). The discovery of this new class of drugs …

Interactions between agents (drugs, carcinogens, physiological stimuli, environmental
pollutants, etc.) in producing their effects are of fundamental interest and practical …

About one-third of human breast cancers require hormones for their continued growth1, and
endocrine ablation or anti-hormone therapy can cause regression of these tumours. As a …

The present treatment of colon cancer is based on 5-fluorouracil (5-FU). Despite promising
results of combining leucovorin or levamisole with 5-FU, the 5-year survival rate of patients …

Drug resistance is one of the major obstacles limiting the success of cancer chemotherapy.
Biological mechanisms contributing to drug resistance may be present de novo and related …

In a prior National Surgical Adjuvant Breast and Bowel Project (NSABP) adjuvant study, the
addition of the antiestrogen tamoxifen to chemotherapy with melphalan and fluorouracil …

Background A prospective randomized clinical trial was implemented to assess whether the
concomitant or the sequential addition of tamoxifen to chemotherapy provides improved …

Aromatase activity has been measured in human breast cancers by incubating tumour
minces with [7α-3H] testosterone and characterizing purified oestradiol (E2) fractions by …

We have performed isobologram analyses of the ability of tamoxifen (TAM) to alter the
response to Adriamycin (ADR) and vinblastine (VBL) in human breast cancer cells. MCF-7 …

The integrated discrete multiple organ co-culture system (IdMOC) allows the co-culturing of
multiple cell types as physically separated cells interconnected by a common overlying …