Antimicrobial peptides as therapeutic agents: Opportunities and challenges

M Mahlapuu, C Björn, J Ekblom - Critical reviews in biotechnology, 2020 - Taylor & Francis
The rapid development of microbial resistance to conventional antibiotics has accelerated
efforts to find anti-infectives with a novel mode-of-action, which are less prone to bacterial …

Antimicrobial peptides: diversity, mechanism of action and strategies to improve the activity and biocompatibility in vivo

P Kumar, JN Kizhakkedathu, SK Straus - Biomolecules, 2018 - mdpi.com
Antibiotic resistance is projected as one of the greatest threats to human health in the future
and hence alternatives are being explored to combat resistance. Antimicrobial peptides …

Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death

C Silvestre-Roig, Q Braster, K Wichapong, EY Lee… - Nature, 2019 - nature.com
The perpetuation of inflammation is an important pathophysiological contributor to the global
medical burden. Chronic inflammation is promoted by non-programmed cell death,; …

Membrane active antimicrobial peptides: translating mechanistic insights to design

J Li, JJ Koh, S Liu, R Lakshminarayanan… - Frontiers in …, 2017 - frontiersin.org
Antimicrobial peptides (AMPs) are promising next generation antibiotics that hold great
potential for combating bacterial resistance. AMPs can be both bacteriostatic and …

The structure-mechanism relationship and mode of actions of antimicrobial peptides: A review

S Li, Y Wang, Z Xue, Y Jia, R Li, C He… - Trends in Food Science & …, 2021 - Elsevier
Background The rapid increase of drug resistance in conventional antibiotics promotes the
discovery and development of antimicrobial peptides (AMPs), which are important …

Hydrophilic nanoparticles that kill bacteria while sparing mammalian cells reveal the antibiotic role of nanostructures

Y Jiang, W Zheng, K Tran, E Kamilar, J Bariwal… - Nature …, 2022 - nature.com
To dissect the antibiotic role of nanostructures from chemical moieties belligerent to both
bacterial and mammalian cells, here we show the antimicrobial activity and cytotoxicity of …

The 2018 biomembrane curvature and remodeling roadmap

P Bassereau, R Jin, T Baumgart… - Journal of physics D …, 2018 - iopscience.iop.org
The importance of curvature as a structural feature of biological membranes has been
recognized for many years and has fascinated scientists from a wide range of different …

Molecular engineering of antimicrobial peptides: Microbial targets, peptide motifs and translation opportunities

P Cardoso, H Glossop, TG Meikle, A Aburto-Medina… - Biophysical …, 2021 - Springer
The global public health threat of antimicrobial resistance has led the scientific community to
highly engage into research on alternative strategies to the traditional small molecule …

Reviewing nanoplastic toxicology: It's an interface problem

S Kihara, I Köper, JP Mata, DJ McGillivray - Advances in Colloid and …, 2021 - Elsevier
Multiple international agencies have recently raised environmental and health concerns
regarding plastics in nanoforms (nanoplastics), but there is insufficient knowledge of their …

Synthetic polypeptide polymers as simplified analogues of antimicrobial peptides

P Salas-Ambrosio, A Tronnet, P Verhaeghe… - …, 2020 - ACS Publications
Antimicrobial peptides (AMPs) are naturally occurring macromolecules made of amino acids
that are potent broad-spectrum antibiotics with potential as novel therapeutic agents. This …