The highly conserved retromer complex controls the fate of hundreds of receptors that pass
through the endolysosomal system and is a central regulatory node for diverse metabolic …

The efficient and prolonged neurotransmission is reliant on the coordinated action of
numerous synaptic proteins in the presynaptic compartment that remodels synaptic vesicles …

A limitation of conventional bulk-tissue proteome studies in amyotrophic lateral sclerosis
(ALS) is the confounding of motor neuron (MN) signals by admixed non-MN proteins. Here …

An NAD+-dependent deacetylase called Sirtuin 3 (Sirt3) is involved in the metabolic
processes of the mitochondria, including energy generation, the tricarboxylic acid cycle, and …

Objective The retromer complex plays an essential role in intracellular endosomal sorting.
Deficits in the retromer complex are linked to enhanced Aβ production. The levels of the …

Endosomal trafficking ensures the proper distribution of lipids and proteins to various
cellular compartments, facilitating intracellular communication, nutrient transport, waste …

Endosomes are crucial sites for intracellular material sorting and transportation. Endosomal
transport is a critical process involved in the selective uptake, processing, and intracellular …

Since the identification of vacuolar protein sorting (VPS) 35, as a causative molecule for
familial Parkinson's disease (PD), retromer-mediated endosomal machinery has been a …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting motor
neurons. Although genes causing familial cases have been identified, those of sporadic …

ABSTRACT Introduction Vacuolar Protein Sorting 35 (VPS35) is pivotal in the retromer
complex, governing transmembrane protein trafficking within cells, and its dysfunction is …