Childhood-onset systemic lupus erythematosus (cSLE) is a prototype of a multisystemic,
inflammatory, heterogeneous autoimmune condition. This disease is characterized by …

Notable advances in gene sequencing methods in recent years have permitted enormous
progress in the phenotypic and genotypic characterization of autoinflammatory syndromes …

In addition to susceptibility to infections, conventional primary immunodeficiency disorders
(PIDs) and inborn errors of immunity (IEI) can cause immune dysregulation, manifesting as …

Type I interferon (IFN-I) mediates tissue damage in a wide range of kidney disorders, directly
affecting the biology and function of several renal cell types including podocytes, mesangial …

Type I interferons (IFNs), mostly IFNα and IFNβ, and the type I IFN Signature are important in
the pathogenesis of Systemic Lupus Erythematosus (SLE), an autoimmune chronic …

Immune thrombocytopenia (ITP) is a common hematological manifestation of systemic lupus
erythematosus (SLE). The heterogeneity of its clinical characteristics and therapeutic …

A 1969 report that described biochemical and activity properties of the three eukaryotic RNA
polymerases revealed Pol III as highly distinguishable, even before its transcripts were …

Background Lupus nephritis (LN) is one of the most severe complications of systemic lupus
erythematosus, with heterogeneous phenotypes and different responses to therapy …

The complement system, an arm of the innate immune system plays a critical role in both
health and disease. The complement system is highly complex with dual possibilities …

Systemic lupus erythematosus (SLE) is a systemic autoimmune/inflammatory disease.
Patients diagnosed with juvenile-onset SLE (jSLE), when compared to individuals with adult …