Basic mechanisms of diabetic heart disease

RH Ritchie, ED Abel - Circulation research, 2020 - Am Heart Assoc
Diabetes mellitus predisposes affected individuals to a significant spectrum of
cardiovascular complications, one of the most debilitating in terms of prognosis is heart …

Guidelines on models of diabetic heart disease

LC Heather, AD Hafstad, GV Halade… - American Journal …, 2022 - journals.physiology.org
Diabetes is a major risk factor for cardiovascular diseases, including diabetic
cardiomyopathy, atherosclerosis, myocardial infarction, and heart failure. As cardiovascular …

Characterization of a mouse model of obesity-related fibrotic cardiomyopathy that recapitulates features of human heart failure with preserved ejection fraction

L Alex, I Russo, V Holoborodko… - American Journal of …, 2018 - journals.physiology.org
Heart failure with preserved ejection fraction (HFpEF) is caused, or exacerbated by, a wide
range of extracardiac conditions. Diabetes, obesity, and metabolic dysfunction are …

Successful induction of diabetes in mice demonstrates no gender difference in development of early diabetic retinopathy

A Saadane, EM Lessieur, Y Du, H Liu, TS Kern - PLoS One, 2020 - journals.plos.org
Purpose Female mice have been found to be resistant to streptozotocin (STZ)-induced
diabetes, and pre-clinical research related to diabetic complications commonly omits …

The role of autophagy in cardiovascular pathology

D Gatica, M Chiong, S Lavandero… - Cardiovascular …, 2022 - academic.oup.com
Macroautophagy/autophagy is a conserved catabolic recycling pathway in which
cytoplasmic components are sequestered, degraded, and recycled to survive various stress …

Exosomal microRNAs miR-30d-5p and miR-126a-5p are associated with heart failure with preserved ejection fraction in STZ-induced type 1 diabetic rats

JP Huang, CC Chang, CY Kuo, KJ Huang… - International journal of …, 2022 - mdpi.com
Exosomal microRNAs (EXO-miRNAs) are promising non-invasive diagnostic biomarkers for
cardiovascular disease. Heart failure with preserved ejection fraction (HFpEF) is a poorly …

Cellular interplay between cardiomyocytes and non-myocytes in diabetic cardiomyopathy

RJ Phang, RH Ritchie, DJ Hausenloy… - Cardiovascular …, 2023 - academic.oup.com
Patients with Type 2 diabetes mellitus (T2DM) frequently exhibit a distinctive cardiac
phenotype known as diabetic cardiomyopathy. Cardiac complications associated with T2DM …

Defining the progression of diabetic cardiomyopathy in a mouse model of type 1 diabetes

MJ De Blasio, N Huynh, M Deo, LE Dubrana… - Frontiers in …, 2020 - frontiersin.org
The incidence of diabetes and its association with increased cardiovascular disease risk
represents a major health issue worldwide. Diabetes-induced hyperglycemia is implicated …

Both male and female obese ZSF1 rats develop cardiac dysfunction in obesity-induced heart failure with preserved ejection fraction

ITN Nguyen, MM Brandt, J van De Wouw… - PLoS …, 2020 - journals.plos.org
Heart failure with a preserved ejection fraction (HFpEF) is associated with multiple
comorbidities, such as old age, hypertension, type 2 diabetes and obesity and is more …

Impact of diabetes and sex in heart failure with reduced ejection fraction patients from the ASIAN‐HF registry

C Chandramouli, THK Teng, WT Tay… - European Journal of …, 2019 - Wiley Online Library
Aims To examine sex differences in clinical characteristics, echocardiographic features,
quality of life and 1‐year death or heart failure (HF) hospitalization outcomes in patients …