Progesterone receptor (PR) is a master regulator in female reproductive tissues that controls
developmental processes and proliferation and differentiation during the reproductive cycle …

Glucocorticoids are among the most prescribed drugs worldwide for the treatment of
numerous immune and inflammatory disorders. They exert their actions by binding to the …

Glucocorticoids (GCs) have been widely used for decades as a first-line treatment for
inflammatory and autoimmune diseases. However, their use is often hampered by the onset …

While the structures of the DNA-and ligand-binding domains of many nuclear receptors have
been determined in great detail; the mechanisms by which these domains interact and …

Intrinsically disordered proteins (IDPs) and IDP regions lack stable tertiary structure yet carry
out numerous biological functions, especially those associated with signaling, transcription …

Allostery is a classical regulatory mechanism of proteins in which a signal at “another
site”(“allos stereos” means another object in Greek) modifies the activity/function of a protein …

Ligands for several transcription factors can act as agonists under some conditions and
antagonists under others. The structural and molecular bases of such effects are unknown …

Therapeutic targeting of nuclear receptors (NRs) is presently restricted due to 2 constraints:
1) a limited knowledge of the structural dynamics of intact receptor when complexed to DNA …

Brain mineralocorticoid receptors (MR s) and glucocorticoid receptors (GR s) respond to the
same glucocorticoid hormones but can have differential effects on cellular function. Several …

Nuclear Factor of Activated T cells 5 (NFAT5) is a transcription factor (TF) that mediates
protection from adverse effects of hypertonicity by increasing transcription of genes …