Preeclampsia (PE) is a multisystemic, pregnancy-specific disorder and a leading cause of
maternal and fetal death. PE is also associated with an increased risk for chronic morbidities …

Preeclampsia (PE) is a placenta-induced inflammatory disease associated with maternal
and fetal morbidity and mortality. The mechanisms underlying PE remain enigmatic and …

The growing nanoparticulate pollution (eg engineered nanoparticles (NPs) or nanoplastics)
has been shown to pose potential threats to human health. In particular, sensitive …

The NFE2 transcription factor was identified over 25 years ago. The NFE2 protein forms
heterodimers with small MAF proteins, and the resulting complex binds to regulatory …

Endoplasmic reticulum (ER) stress is associated with diabetic nephropathy (DN), but its
pathophysiological relevance and the mechanisms that compromise adaptive ER signalling …

Established therapies for diabetic nephropathy (dNP) delay but do not prevent its
progression. The shortage of established therapies may reflect the inability to target the …

Ischemia-reperfusion injury (IRI) is the leading cause of ARF. A pathophysiologic role of the
coagulation system in renal IRI has been established, but the functional relevance of …

A central determinant of pregnancy success is proper development of the conceptus
(embryo/fetus and associated extraembryonic membranes including the placenta). Although …

Placentation is a process that establishes the maternal-fetal interface and is required for
successful pregnancy. The epithelial component of the placenta consists of trophoblast cells …

The role of the chorio-allantoic placenta as the critical nutrient-and oxygen-supplying organ
to nourish the demands of the fetus has been well recognized. This function relies on the …