After cell entry, human immunodeficiency virus type 1 (HIV-1) replication involves reverse
transcription of the RNA genome, nuclear import of the subviral complex without nuclear …

Gene expression universally relies on protein synthesis, where ribosomes recognize and
decode the messenger RNA template by cycling through translation initiation, elongation …

Molecular dynamics (MD) simulation has become a powerful tool for characterizing at an
atomic level of detail the conformational changes undergone by proteins. The application of …

Swinging arms are a key functional component of multistep catalytic transformations in many
naturally occurring multi-enzyme complexes. This arm is typically a prosthetic chemical …

In this manuscript, we compare different analytical methodologies to validate or disprove the
binding capabilities of aptamer sequences. This was prompted by the lack of a universally …

Nanomanufacturing, the commercially scalable and economically sustainable mass
production of nanoscale materials and devices, represents the tangible outcome of the …

Electrochemical aptamer-based (E-AB) sensors are a versatile sensing platform that can
achieve rapid and robust target detection in complex matrices. However, the limited …

Although it is known that RNA undergoes liquid–liquid phase separation, the interplay
between the molecular driving forces and the emergent features of the condensates, such as …

Although molecular dynamics (MD) simulations have been used extensively to study the
structural dynamics of proteins, the role of MD simulation in studies of nucleic acid based …

The programmed− 1 ribosomal frameshifting element (PFSE) of SARS-CoV-2 is a well
conserved structured RNA found in all coronaviruses' genomes. By adopting a pseudoknot …