Mast cells (MCs) are portions of the innate and adaptive immune system derived from bone
marrow (BM) progenitors that are rich in cytoplasmic granules. MC maturation, phenotype …

Immune responses in the CNS are common, despite its perception as a site of immune
privilege. These responses can be mediated by resident microglia and astrocytes, which are …

Mast cells and basophils are potent effector cells of the innate immune system, and they
have both beneficial and detrimental functions for the host. They are mainly implicated in pro …

It is well recognized that neuroinflammation is involved in the pathogenesis of various
neurodegenerative diseases. Microglia and astrocytes are major pathogenic components …

Immunological functions of mast cells are currently considered to be much broader than the
original role of mast cells in IgE-driven allergic disease. The spectrum of proposed mast cell …

In addition to their well-accepted role as critical effector cells in anaphylaxis and other acute
IgE-mediated allergic reactions, mast cells (MCs) have been implicated in a wide variety of …

The meninges are often considered inert tissues that house the CSF and provide protection
for the brain and spinal cord. Yet emerging data demonstrates that they are also active sites …

Substantial evidence indicates that stress can precipitate or worsen symptoms of
inflammation in general and more specifically in multiple sclerosis (MS), a demyelinating …

The roles of mast cells in health and disease remain incompletely understood. While the
evidence that mast cells are critical effector cells in IgE-dependent anaphylaxis and other …

UV radiation targets the skin and is a primary cause of skin cancer (both melanoma and
nonmelanoma skin cancer). Exposure to UV radiation also suppresses the immune …