Abstract Amylin [1–3], the major peptide component of the islet amyloid [1] commonly found
in the pancreases of patients with type 2 (non-insulin-dependent) diabetes mellitus …

Strong epidemiologic evidence and common molecular mechanisms support an association
between Alzheimer's disease (AD) and type 2-diabetes. Local inflammation and amyloidosis …

Diabetes-associated peptide has recently been isolated and characterized from the amyloid
of the islets of Langerhans in type 2 (non-insulin-dependent) diabetics, and …

Strong epidemiologic evidence suggests an association between Alzheimer disease (AD)
and type 2 diabetes. To determine if amyloid beta (Aβ) and hyperphosphorylated tau occurs …

Amyloid deposits occurring in the islets of Langerhans in patients with noninsulin-dependent
diabetes mellitus and some insulinomas contain a 37-amino acid peptide that is structurally …

During hyperinsulinemic glucose-clamp studies, intravenous infusion of calcitonin gene-
related peptide (CGRP) in rats antagonized the ability of insulin to stimulate peripheral …

Islet amyloid polypeptide (IAPP) is a 37-amino acid peptide found in the pancreatic amyloid
deposits of type II (non-insulin-dependent) diabetic patients and insulinomas. We previously …

Accumulating evidence suggests that Alzheimer's disease may manifest as a metabolic
disorder with pathology and/or dysfunction in numerous tissues. Adults with Alzheimer's …

Islet amyloid polypeptide (IAPP) is the 37‐amino acid peptide subunit of amyloid found in
pancreatic islets of type 2 diabetic patients and in insulinomas. Recently, we isolated the …

Chapter 1 2 mechanisms and peptide drug delivery, including cell permeability to prosecute
intracellular targets, is re-defining the term “druggability”. Beyond such convergent …