Circular RNA ITCH: A novel tumor suppressor in multiple cancers

Y Li, Y Ge, L Xu, R Jia - Life sciences, 2020 - Elsevier
Circular RNAs (circRNAs) are a new type of endogenous noncoding RNAs with closed
circular structure. Emerging evidence indicates that circRNAs play crucial roles in many …

Circular RNA HIPK3: a key circular RNA in a variety of human cancers

J Wen, J Liao, J Liang, X Chen, B Zhang… - Frontiers in …, 2020 - frontiersin.org
Circular RNAs (circRNAs), which act as initiators and promoters of various diseases, were
thought to be mostly noncoding RNAs (ncRNAs) in eukaryotes, until recent studies …

Circular RNA ITCH suppresses metastasis of gastric cancer via regulating miR-199a-5p/Klotho axis

Y Wang, H Wang, R Zheng, P Wu, Z Sun, J Chen… - Cell Cycle, 2021 - Taylor & Francis
Circular RNAs (circRNAs) are considered as a new regulatory factor in growth, metastasis
and therapeutic resistance of human cancers. But the clinical significance and underlying …

CircHIPK3 overexpression accelerates the proliferation and invasion of prostate cancer cells through regulating miRNA-338-3p

C Cai, Y Zhi, K Wang, P Zhang, Z Ji, C Xie… - OncoTargets and …, 2019 - Taylor & Francis
Objective Circular RNA is a type of endogenous RNA molecule with a stable closed-loop
structure which is ubiquitous in mammals. Circular RNA HIPK3 (circHIPK3) is highly …

Functions of circular RNAs and their potential applications in gastric cancer

Y Ruan, Z Li, Y Shen, T Li, H Zhang… - Expert Review of …, 2020 - Taylor & Francis
Introduction: In recent years, circular RNAs (circRNAs) have emerged in the field of RNA
research and their biological functions are now being gradually identified. circRNAs are …

[HTML][HTML] CircHIPK3: a promising cancer-related circular RNA

Y Zhang, Q Liu, Q Liao - American Journal of Translational …, 2020 - ncbi.nlm.nih.gov
Circular RNA (circRNA) is a special type of endogenous noncoding RNAs (ncRNAs), and
are characterized by a covalently closed loop structure without a 5'cap and poly-adenylated …

The circular RNA HIPK3 (circHIPK3) and its regulation in cancer progression

Y Xie, X Yuan, W Zhou, AA Kosiba, H Shi, J Gu, Z Qin - Life sciences, 2020 - Elsevier
Circular RNAs (circRNAs) are a class of covalently closed continuous loops of single-
stranded RNA molecules, and broadly expressed in the cytoplasm of eukaryotic cells …

CircRNA ITCH increases bortezomib sensitivity through regulating the miR-615-3p/PRKCD axis in multiple myeloma

J Liu, F Du, C Chen, D Li, Y Chen, X Xiao, X Hou - Life Sciences, 2020 - Elsevier
Aims Bortezomib (BTZ) is described as the first-line agent for multiple myeloma (MM)
chemotherapy, but the emergence of BTZ resistance usually results in the failure of …

CircHIPK3 alleviates high glucose toxicity to human renal tubular epithelial HK-2 cells through regulation of miR-326/miR-487a-3p/SIRT1

L Zhuang, Z Wang, X Hu, Q Yang, X Pei… - … Syndrome and Obesity, 2021 - Taylor & Francis
Background The intervention of circular RNA HIPK3 (circHIPK3) in diabetes has drawn
increasing attention in recent years. However, the underlying mechanism of circHIPK3 in …

CircHIPK3 Promotes Metastasis of Gastric Cancer via miR-653-5p/miR-338-3p-NRP1 Axis Under a Long-Term Hypoxic Microenvironment

Y Jin, X Che, X Qu, X Li, W Lu, J Wu, Y Wang… - Frontiers in …, 2020 - frontiersin.org
As a vital feature of the microenvironment, hypoxia, especially long-term hypoxia, is known
to promote metastasis and lead to poor prognosis in solid tumors. Circular RNAs (circRNAs) …