Interleukins and associated cytokines serve as the means of communication for innate and
adaptive immune cells as well as non-immune cells and tissues. Thus, interleukins have a …

Oncolytic viruses (OVs) are emerging as potentially useful platforms in treatment methods for
patients with tumors. They preferentially target and kill tumor cells, leaving healthy cells …

Group 2 innate lymphoid cells (ILC2s) are essential to maintain tissue homeostasis. In
cancer, ILC2s can harbor both pro-tumorigenic and anti-tumorigenic functions, but we know …

Cytokines play a critical role in regulating host immune response toward cancer and
determining the overall fate of tumorigenesis. The tumor microenvironment is dominated …

Immunotherapies targeting conventional T cells have revolutionized systemic treatment for
many cancers, yet only a subset of patients benefit from these approaches. A better …

The immunosuppressive tumor microenvironment (TME) is a major barrier to
immunotherapy. Within solid tumors, why monocytes preferentially differentiate into …

Research on obesity-and diabetes mellitus (DM)-related carcinogenesis has expanded
exponentially since these two diseases were recognized as important risk factors for …

The tumor microenvironment (TME) is a critical regulator of tumor growth, progression, and
metastasis. Since immune cells represent a large fraction of the TME, they play a key role in …

BACKGROUND Immune-related adverse events (irAEs) and their associated
morbidity/mortality are a key concern for patients receiving immune checkpoint inhibitors …

Acquired resistance to chemotherapy remains a major stumbling block in cancer treatment.
Chronic inflammation has a crucial role in induction of chemoresistance and results, in part …