Many neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis, are characterized by the progressive appearance of abnormal …

Prion-like propagation of tau aggregation might underlie the stereotyped progression of
neurodegenerative tauopathies. True prions stably maintain unique conformations (" …

Prions derived from the prion protein (PrP) were first characterized as infectious agents that
transmit pathology between individuals. However, the majority of cases of …

Objective Several prion amplification systems have been proposed for detection of prions in
cerebrospinal fluid (CSF), most recently, the measurements of prion seeding activity with …

Genetic and environmental factors that increase the risk of late-onset Alzheimer disease are
now well recognized but the cause of variable progression rates and phenotypes of sporadic …

Although genetic factors play a main role in determining the risk of developing Alzheimer's
disease (AD), they do not explain extensive spectrum of clinicopathological phenotypes …

Alzheimer's disease (AD) brain tissue can act as a seed to accelerate aggregation of
amyloid-β (Aβ) into plaques in AD transgenic mice. Aβ seeds have been hypothesized to …

Amyloid beta (Aβ) deposition in the neocortex is a major hallmark of Alzheimer's disease
(AD), but the extent of deposition does not readily explain phenotypic diversity and rate of …

Vast evidence on human prions demonstrates that variable disease phenotypes, rates of
propagation, and targeting of distinct brain structures are determined by unique conformers …

Intra-or extracellular aggregates of proteins are central pathogenic features in most
neurodegenerative disorders. The accumulation of such proteins in diseased brains is …