Macroautophagy/autophagy is primarily accountable for the degradation of damaged
organelles and toxic macromolecules in the cells. Regarding the essential function of …

Uromodulin (also known as Tamm–Horsfall protein) is a kidney-specific glycoprotein
secreted bidirectionally into urine and into the circulation, and it is the most abundant protein …

During tumor expansion, breast cancer (BC) cells often experience reactive oxygen species
accumulation and mitochondrial damage because of glucose shortage. However, the …

The conserved mesencephalic astrocyte-derived neurotrophic factor (MANF) is known for
protecting dopaminergic neurons and functioning in various other tissues. Previously, we …

Acute kidney injury (AKI) is a significant global health issue, which is often caused by
cisplatin therapy and characterized by mitochondrial dysfunction. Restoring mitochondrial …

Background Myocardial ischemia/reperfusion (I/R) injury is a common pathological process
in clinical practice. Developing effective therapeutic strategies to reduce or prevent this …

Abstract Background Chaihuang Yishen Granules (CHYS) has been clinically proven to be
effective for the treatment of chronic kidney disease (CKD), yet its underlying molecular …

Mitophagy is a highly precise process of selective autophagy, primarily aimed at eliminating
excess or damaged mitochondria to maintain the stability of both mitochondrial and cellular …

Intervertebral disc degeneration (IDD) is a degenerative condition associated with impaired
mitophagy. MANF has been shown to promote mitophagy in murine kidneys; however, its …

Polycystic kidney disease (PKD) is the most common genetic form of chronic kidney disease
(CKD), and it involves the development of multiple kidney cysts. Not enough medical …