Vascular smooth muscle cells in atherosclerosis: time for a re-assessment

MOJ Grootaert, MR Bennett - Cardiovascular research, 2021 - academic.oup.com
Vascular smooth muscle cells (VSMCs) are key participants in both early and late-stage
atherosclerosis. VSMCs invade the early atherosclerotic lesion from the media, expanding …

Cardiovascular calcification heterogeneity in chronic kidney disease

JD Hutcheson, C Goettsch - Circulation research, 2023 - Am Heart Assoc
Patients with chronic kidney disease (CKD) exhibit tremendously elevated risk for
cardiovascular disease, particularly ischemic heart disease, due to premature vascular and …

Arterial stiffness: a focus on vascular calcification and its link to bone mineralization

Y Chen, X Zhao, H Wu - Arteriosclerosis, thrombosis, and vascular …, 2020 - Am Heart Assoc
This review focuses on the association between vascular calcification and arterial stiffness,
highlighting the important genetic factors, systemic and local microenvironmental signals …

From organic and inorganic phosphates to valvular and vascular calcifications

M Bäck, JB Michel - Cardiovascular Research, 2021 - academic.oup.com
Calcification of the arterial wall and valves is an important part of the pathophysiological
process of peripheral and coronary atherosclerosis, aortic stenosis, ageing, diabetes, and …

The role of coagulome in the tumor immune microenvironment

R Wahab, MM Hasan, Z Azam, PJ Grippo… - Advanced drug delivery …, 2023 - Elsevier
The rising incidence and persistent thrombosis in multiple cancers including those that are
immunosuppressive highlight the need for understanding the tumor coagulome system and …

Vascular smooth muscle cells in intracranial aneurysms

Z Wang, J Ma, H Yue, Z Zhang, F Fang, G Wang… - Microvascular …, 2023 - Elsevier
Intracranial aneurysm (IA) is a severe cerebrovascular disease characterized by abnormal
bulging of cerebral vessels that may rupture and cause a stroke. The expansion of the …

Mechanisms of the osteogenic switch of smooth muscle cells in vascular calcification: WNT signaling, BMPs, mechanotransduction, and EndMT

J Tyson, K Bundy, C Roach, H Douglas, V Ventura… - Bioengineering, 2020 - mdpi.com
Characterized by the hardening of arteries, vascular calcification is the deposition of
hydroxyapatite crystals in the arterial tissue. Calcification is now understood to be a cell …

Wnt signaling in vascular calcification

K Bundy, J Boone, CLS Simpson - Frontiers in Cardiovascular …, 2021 - frontiersin.org
Cardiovascular disease is a worldwide epidemic and considered the leading cause of death
globally. Due to its high mortality rates, it is imperative to study the underlying causes and …

Plaque calcification: do lipoproteins have a role?

EJ Akers, SJ Nicholls, BA Di Bartolo - … , thrombosis, and vascular …, 2019 - Am Heart Assoc
Vascular calcification (VC) is strongly associated with all-cause mortality and is an
independent predictor of cardiovascular events. Resulting from its complex, multifaceted …

Vascular calcification mechanisms: updates and renewed insight into signaling pathways involved in high phosphate-mediated vascular smooth muscle cell …

N Abbasian - Biomedicines, 2021 - mdpi.com
Vascular calcification (VC) is associated with aging, cardiovascular and renal diseases and
results in poor morbidity and increased mortality. VC occurs in patients with chronic kidney …