Viral infections can cause serious diseases for humans and animals. Accurate and early
detection of viruses is often crucial for clinical diagnosis and therapy. Aptamers are mostly …

Like all retroviruses, the human immunodeficiency virus selectively packages two copies of
its unspliced RNA genome, both of which are utilized for strand-transfer-mediated …

Despite antiretroviral therapy, HIV-1 persists in memory CD4+ T cells, creating a barrier to
cure. The majority of HIV-1 proviruses are defective and considered clinically irrelevant …

A retroviral vector system based on the human immunodeficiency virus (HIV) was developed
that, in contrast to a murine leukemia virus-based counterpart, transduced heterologous …

Vectors derived from human immunodeficiency virus (HIV) are highly efficient vehicles for in
vivo gene delivery. However, their biosafety is of major concern. Here we exploit the …

We describe the construction of a safe, replication-defective and efficient lentiviral vector
suitable for in vivo gene delivery. The reverse transcription of the vector was found to be a …

The HIV-1 Gag protein orchestrates all steps of virion genesis, including membrane
targeting and RNA recruitment into virions. Using crosslinking-immunoprecipitation (CLIP) …

Ribonucleoprotein (RNP) granules are membraneless condensates that organize the
intracellular space by compartmentalization of specific RNAs and proteins. Studies have …

The three-dimensional structure of the human immunodeficiency virus–type 1 (HIV-1)
nucleocapsid protein (NC) bound to the SL3 stem-loop recognition element of the genomic …

To identify RNA and protein sequences involved in packaging of human immunodeficiency
virus type 1 (HIV-1), various mutations were introduced into the viral genome. Portions of the …