Axonal modulation of striatal dopamine release by local γ-aminobutyric acid (GABA) signalling

BM Roberts, EF Lopes, SJ Cragg - Cells, 2021 - mdpi.com
Striatal dopamine (DA) release is critical for motivated actions and reinforcement learning,
and is locally influenced at the level of DA axons by other striatal neurotransmitters. Here …

Mini-Review: Effects of Ethanol on GABAA Receptor-Mediated Neurotransmission in the Cerebellar Cortex—Recent Advances

CF Valenzuela, K Jotty - The Cerebellum, 2015 - Springer
Studies from several laboratories have shown that ethanol impairs cerebellar function, in
part, by altering GABAergic transmission. Here, we discuss recent advances in our …

Axonal mechanisms mediating γ-aminobutyric acid receptor type A (GABA-A) inhibition of striatal dopamine release

PF Kramer, EL Twedell, JH Shin, R Zhang, ZM Khaliq - Elife, 2020 - elifesciences.org
Axons of dopaminergic neurons innervate the striatum where they contribute to movement
and reinforcement learning. Past work has shown that striatal GABA tonically inhibits …

Axonal conduction delays, brain state, and corticogeniculate communication

CR Stoelzel, Y Bereshpolova, JM Alonso… - Journal of …, 2017 - Soc Neuroscience
Thalamocortical conduction times are short, but layer 6 corticothalamic axons display an
enormous range of conduction times, some exceeding 40–50 ms. Here, we investigate (1) …

Axonal GABAA receptors depolarize presynaptic terminals and facilitate transmitter release in cerebellar Purkinje cells

J Zorrilla de San Martin, FF Trigo… - The Journal of …, 2017 - Wiley Online Library
Key points GABAA receptors have been described in the axonal compartment of neurons;
contrary to dendritic GABAA receptors, axonal GABAA receptors usually induce depolarizing …

Revisiting a theory of cerebellar cortex

T Yamazaki, W Lennon - Neuroscience research, 2019 - Elsevier
Long-term depression at parallel fiber-Purkinje cell synapses plays a principal role in
learning in the cerebellum, which acts as a supervised learning machine. Recent …

Axonal GABAA stabilizes excitability in unmyelinated sensory axons secondary to NKCC1 activity

V Bonalume, L Caffino, LF Castelnovo… - The Journal of …, 2021 - Wiley Online Library
Key points GABA depolarized sural nerve axons and increased the electrical excitability of C‐
fibres via GABAA receptor. Axonal excitability responses to GABA increased monotonically …

Attenuation of sensory transmission through the rat trigeminal ganglion by GABA receptor activation

MR Ekbatan, BE Cairns - Neuroscience, 2021 - Elsevier
While the trigeminal ganglion is often considered a passive conduit of sensory transmission,
neurons and satellite glial cells (SGCs) within it can release neurotransmitters and express …

Presynaptic ionotropic receptors in the cerebellar cortex: Just the tip of the iceberg?

FF Trigo, T Collin, I Llano, A Marty - Neuroscience, 2024 - Elsevier
The presence of ionotropic receptors to neurotransmitters in presynaptic structures is well
documented in many synapses of the mammalian brain. However, due to technical …

FHF-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon

K Dover, C Marra, S Solinas, M Popovic… - Nature …, 2016 - nature.com
Neurons in vertebrate central nervous systems initiate and conduct sodium action potentials
in distinct subcellular compartments that differ architecturally and electrically. Here, we …