The assembly of ribosomal subunits is a highly orchestrated process that involves a huge
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …

In the past 25 years, genetic and biochemical analyses of ribosome assembly in yeast have
identified most of the factors that participate in this complex pathway and have generated …

Eukaryotic ribosome synthesis is a complex, energy-consuming process that takes place
across the nucleolus, nucleoplasm and cytoplasm and requires more than 200 conserved …

Targeted proteomics technique has emerged as a powerful protein quantification tool in
systems biology, biomedical research, and increasing for clinical applications. The most …

The enormous diversity of proteoforms produces tremendous complexity within cellular
proteomes, facilitates intricate networks of molecular interactions, and constitutes a …

Ribosome synthesis is catalyzed by∼ 200 assembly factors, which facilitate efficient
production of mature ribosomes. Here, we determined the cryo-EM structure of a …

Accurate translation of the genetic code into functional polypeptides is key to cellular growth
and proliferation. This essential process is carried out by the ribosome, a ribonucleoprotein …

Eukaryotic ribosome biogenesis depends on several hundred assembly factors to produce
functional 40S and 60S ribosomal subunits. The final phase of 60S subunit biogenesis is …

Ribosome biogenesis requires the intertwined processes of folding, modification, and
processing of ribosomal RNA, together with binding of ribosomal proteins. In eukaryotic …

RNA modifications are widespread in biology and abundant in ribosomal RNA. However,
the importance of these modifications is not well understood. We show that methylation of a …