Sleep and anxiety: From mechanisms to interventions

SL Chellappa, D Aeschbach - Sleep medicine reviews, 2022 - Elsevier
Anxiety is the most common mental health problem worldwide. Epidemiological studies
show that sleep disturbances, particularly insomnia, affect∼ 50% of individuals with anxiety …

Midbrain projection to the basolateral amygdala encodes anxiety-like but not depression-like behaviors

C Morel, SE Montgomery, L Li… - Nature …, 2022 - nature.com
Anxiety disorders are complex diseases, and often co-occur with depression. It is as yet
unclear if a common neural circuit controls anxiety-related behaviors in both anxiety-alone …

Emotion processing dysfunction in Alzheimer's disease: an overview of behavioral findings, systems neural correlates, and underlying neural biology

S Chaudhary, S Zhornitsky, HH Chao… - American Journal of …, 2022 - journals.sagepub.com
We described behavioral studies to highlight emotional processing deficits in Alzheimer's
disease (AD). The findings suggest prominent deficit in recognizing negative emotions …

Genome-wide meta-analysis, functional genomics and integrative analyses implicate new risk genes and therapeutic targets for anxiety disorders

W Li, R Chen, L Feng, X Dang, J Liu, T Chen… - Nature Human …, 2024 - nature.com
Anxiety disorders are the most prevalent mental disorders. However, the genetic etiology of
anxiety disorders remains largely unknown. Here we conducted a genome-wide meta …

The cerebellum and anxiety

PW Chin, GJ Augustine - Frontiers in Cellular Neuroscience, 2023 - frontiersin.org
Although the cerebellum is traditionally known for its role in motor functions, recent evidence
points toward the additional involvement of the cerebellum in an array of non-motor …

Midbrain dopamine controls anxiety-like behavior by engaging unique interpeduncular nucleus microcircuitry

SR DeGroot, R Zhao-Shea, L Chung, PM Klenowski… - Biological …, 2020 - Elsevier
Background Dopamine (DA) is hypothesized to modulate anxiety-like behavior, although the
precise role of DA in anxiety behaviors and the complete anxiety network in the brain have …

Electroacupuncture alleviates chronic pain-induced anxiety disorders by regulating the rACC-thalamus circuitry

Z Shen, H Zhang, Z Wu, Q He, J Liu, Y Xu… - Frontiers in …, 2021 - frontiersin.org
Anxiety is a common comorbidity associated with chronic pain, which results in chronic pain
complexification and difficulty in treatment. Electroacupuncture (EA) is commonly used to …

[HTML][HTML] Cell type specificity for circuit output in the midbrain dopaminergic system

S Blaess, S Krabbe - Current opinion in neurobiology, 2023 - Elsevier
Midbrain dopaminergic neurons are a relatively small group of neurons in the mammalian
brain controlling a wide range of behaviors. In recent years, increasingly sophisticated …

Current Perspectives on Selective Dopamine D3 Receptor Antagonists/Partial Agonists as Pharmacotherapeutics for Opioid and Psychostimulant Use Disorders

AH Newman, ZX Xi, C Heidbreder - … Function: New Insight After 30 Years …, 2022 - Springer
Over three decades of evidence indicate that dopamine (DA) D3 receptors (D3R) are
involved in the control of drug-seeking behavior and may play an important role in the …

Oxytocin modulates neurocomputational mechanisms underlying prosocial reinforcement learning

D Martins, P Lockwood, J Cutler, R Moran… - Progress in …, 2022 - Elsevier
Humans often act in the best interests of others. However, how we learn which actions result
in good outcomes for other people and the neurochemical systems that support this …