Nanoparticles (NPs) serve to reduce the toxicity, enhance bioactivity, improve targeting, and
provide versatile means to control the release profile of the encapsulated moiety. Among …

The authors were asked by the Editors of ACS Chemical Biology to write an article titled
“Why Nature Chose Selenium” for the occasion of the upcoming bicentennial of the …

Unlike other essential trace elements that interact with proteins in the form of cofactors,
selenium (Se) becomes co-translationally incorporated into the polypeptide chain as part of …

The concept of cell signaling in the context of nonenzyme-assisted protein modifications by
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …

Cysteine is one of the least abundant amino acids, yet it is frequently found as a highly
conserved residue within functional (regulatory, catalytic, or binding) sites in proteins. It is …

Selenium is an essential micronutrient with important functions in human health and
relevance to several pathophysiological conditions. The biological effects of selenium are …

The selenoprotein glutathione peroxidase 4 (GPX4) is one of the main antioxidant mediators
in the human body. Its central function involves the reduction of complex hydroperoxides into …

BACKGROUND: Glutathione-dependent catalysis is a metabolic adaptation to chemical
challenges encountered by all life forms. In the course of evolution, nature optimized …

Background With cancer cells encompassing consistently higher production of reactive
oxygen species (ROS) and with an induced antioxidant defense to counteract the increased …

The cysteine (Cys) proteome is a major component of the adaptive interface between the
genome and the exposome. The thiol moiety of Cys undergoes a range of biologic …