Nonribosomal peptide synthetases (NRPSs) are large multienzyme machineries that
assemble numerous peptides with large structural and functional diversity. These peptides …

Natural product libraries contain specialized metabolites derived from plants, animals, and
microorganisms that play a pivotal role in drug discovery due to their immense structural …

Microorganisms have a long track record as important sources of novel bioactive natural
products, particularly in the field of drug discovery. While microbes have been shown to …

The textile and dyeing industry has shown dramatic growth alongside synthetic chemistry in
the last century. With increased operations and economic importance, challenges also …

Interest in therapeutic discovery typically drives the preparation of natural product analogs,
but these undertakings contribute significant advances for synthetic chemistry as well. The …

Actinomycetes have been proven to be an excellent source of secondary metabolites for
more than half a century. Exhibiting various bioactivities, they provide valuable approved …

Covering: up to 2018 With contributions from the global natural product (NP) research
community, and continuing the Raw Data Initiative, this review collects a comprehensive …

Synthetic biology is touted as the next industrial revolution as it promises access to greener
biocatalytic syntheses to replace many industrial organic chemistries. Here, it is shown to …

Flavoprotein monooxygenases create valuable compounds that are of high interest for the
chemical, pharmaceutical, and agrochemical industries, among others. Monooxygenases …

Bioactive compound design based on natural product (NP) structure may be limited because
of partial coverage of NP‐like chemical space and biological target space. These limitations …