Malaria parasite plasmepsins: More than just plain old degradative pepsins

AS Nasamu, AJ Polino, ES Istvan… - Journal of Biological …, 2020 - ASBMB
Plasmepsins are a group of diverse aspartic proteases in the malaria parasite Plasmodium.
Their functions are strikingly multifaceted, ranging from hemoglobin degradation to secretory …

In vitro and in silico studies of naphthoquinones and peptidomimetics toward Plasmodium falciparum plasmepsin V

P Sittikul, N Songtawee, N Kongkathip, N Boonyalai - Biochimie, 2018 - Elsevier
Plasmodium proteases play both regulatory and effector roles in essential biological
processes in this important pathogen and have long been investigated as drug targets …

Plasmepsin: Function, characterization and targeted antimalarial drug development

P Liu - Natural remedies in the fight against parasites, 2017 - books.google.com
The devastating malaria, caused by parasites of the genus Plasmodium, afflicts nearly half of
the world's population and imposes a heavy socio-economic burden particularly to the …

Yield improvement and enzymatic dissection of Plasmodium falciparum plasmepsin V

C Loymunkong, P Sittikul, N Songtawee… - Molecular and …, 2019 - Elsevier
To survive within a red blood cell (RBC), malaria parasites establish striking modifications to
the permeability, rigidity and cytoadherence properties of the host cell. This is mediated by …

Inhibitory Effect of Some Flavones on Plasmodium falciparum Plasmepsin V Activity

OO Aje - 2023 - search.proquest.com
Malaria is a devastating illness, and its management can solely be accomplished via
chemotherapy. Prompt development as well as a search and discovery of treatment with …

[PDF][PDF] Flag Acidic Target Tag (FATT) Improves Solubility and Production Yield of Recombinant P. falciparum Plasmepsin V (PfPMV)

C Loymunkong, R Wongpanya, N Boonyalai - kukr.lib.ku.ac.th
Plasmepsin V from Plasmodium falciparum (PfPMV) plays a major role in the cleavage of the
exported protein containing Plasmodium export element (PEXEL) motif. PfPMV is vital for …