Viral membrane fusion: a dance between proteins and lipids

JM White, AE Ward, L Odongo… - Annual review of …, 2023 - annualreviews.org
There are at least 21 families of enveloped viruses that infect mammals, and many contain
members of high concern for global human health. All enveloped viruses have a dedicated …

Review of eukaryote cellular membrane lipid Composition, with special attention to the fatty acids

O Ali, A Szabó - International Journal of Molecular Sciences, 2023 - mdpi.com
Biological membranes, primarily composed of lipids, envelop each living cell. The intricate
composition and organization of membrane lipids, including the variety of fatty acids they …

OPA1 helical structures give perspective to mitochondrial dysfunction

SB Nyenhuis, X Wu, MP Strub, YI Yim, AE Stanton… - Nature, 2023 - nature.com
Dominant optic atrophy is one of the leading causes of childhood blindness. Around 60–
80% of cases are caused by mutations of the gene that encodes optic atrophy protein 1 …

Phosphatidylethanolamine and cholesterol promote hemifusion formation: A tug of war between membrane interfacial order and intrinsic negative curvature of lipids

S Mishra, H Chakraborty - The Journal of Physical Chemistry B, 2023 - ACS Publications
Membrane fusion is an important process for the survival of eukaryotes. The shape of lipids
plays an important role in fusion by stabilizing nonlamellar fusion intermediates. Lipids with …

Lipid-based nanocarriers challenging the ocular biological barriers: Current paradigm and future perspectives

KK Abla, MM Mehanna - Journal of Controlled Release, 2023 - Elsevier
Eye is the most specialized and sensory body organ and treating eye diseases efficiently is
necessary. Despite various attempts, the design of a consummate ophthalmic drug delivery …

The battle of lipid-based nanocarriers against blood-brain barrier: A critical review

KK Abla, MM Mehanna - Journal of Drug Targeting, 2023 - Taylor & Francis
Central nervous system integrity is the state of brain functioning across sensory, cognitive,
emotional-social behaviors, and motor domains, allowing a person to realise his full …

Tuning the extracellular vesicles membrane through fusion for biomedical applications

M Karmacharya, S Kumar, YK Cho - Journal of Functional Biomaterials, 2023 - mdpi.com
Membrane fusion is one of the key phenomena in the living cell for maintaining the basic
function of life. Extracellular vesicles (EVs) have the ability to transfer information between …

The local variation of the Gaussian modulus enables different pathways for fluid lipid vesicle fusion

M Bottacchiari, M Gallo, M Bussoletti, CM Casciola - Scientific Reports, 2024 - nature.com
Viral infections, fertilization, neurotransmission, and many other fundamental biological
processes rely on membrane fusion. Straightforward calculations based on the celebrated …

Xenopus Oocytes as a Powerful Cellular Model to Study Foreign Fully-Processed Membrane Proteins

I Ivorra, A Alberola-Die, R Cobo, JM González-Ros… - Membranes, 2022 - mdpi.com
The use of Xenopus oocytes in electrophysiological and biophysical research constitutes a
long and successful story, providing major advances to the knowledge of the function and …

Nanoscale structural response of biomimetic cell membranes to controlled dehydration

E Krok, HG Franquelim, M Chattopadhyay… - Nanoscale, 2024 - pubs.rsc.org
Although cell membranes exist in excess of water under physiological conditions, there are
a number of biochemical processes, such as adsorption of biomacromolecules or …