Graft-versus-host disease (GvHD) was first recognized in murine models of HSCT, and in the
absence of knowledge of the HLA system, it was termed “secondary”(secondary to recovery …

Acute graft-versus-host disease (aGVHD) is a major life-threatening complication after
allogeneic hematopoietic cell transplant. Traditional standard prophylaxis for aGVHD has …

Corticosteroid treatment (CST) failure is associated with poor outcomes for patients with
gastrointestinal (GI) graft-versus-host disease (GVHD). CST is intended to target the immune …

Acute liver failure (ALF) is a life‐threatening medical condition, characterized by rapidly
progressive hepatic dysfunction, coagulopathy and hepatic encephalopathy in patients …

Disruptions to the gut microbiota have been associated with adverse outcomes including
graft-versus-host disease, infections, and mortality after hematopoietic cell transplantation …

Despite significant achievements in hematopoietic stem cell transplantation (HSCT), graft-
versus-host disease (GVHD), especially intestinal GVHD, remains a major obstacle to this …

Metabolic dysfunction-associated steatotic liver disease (MASLD) comprises a spectrum of
liver diseases that span simple steatosis, metabolic dysfunction-associated steatohepatitis …

Treatments that aid inflammation resolution, immune tolerance, and epithelial repair may
improve outcomes beyond high-dose corticosteroids and other broad immunosuppressants …

Refractory acute graft-versus-host disease (GVHD) occurs when the immune injury exceeds
the capacity of injured tissues to regenerate and repair. While glucocorticoids have been …

Despite its importance for generating and maintaining a healthy and broad T cell repertoire,
the thymus is exquisitely sensitive to acute damage. Marked thymic involution occurs in …