Infection with the protozoan parasite Trypanosoma cruzi, the agent of Chagas disease, is
characterised by a variable clinical course–from symptomless cases to severe chronic …

We investigated the kinetics of parasite replication, leukocyte migration, and
cytokine/chemokine mRNA expression in the heart tissue from animals infected with the …

The mechanisms involved in the pathology of chronic chagasic cardiomyopathy are still
debated, and the controversy has interfered with the development of new treatments and …

The determinants of the prevalence of CD8+ T cells in the inflamed myocardium of
Trypanosoma cruzi-infected patients and experimental animals are undefined. Using …

Abstract UNC93B1 associates with TLR3, 7, and 9, mediating their translocation from the
endoplasmic reticulum to the endolysosome, thus allowing proper activation by microbial …

In this study, we have evaluated the production of pro‐and anti‐inflammatory cytokines and
the formation of central and effector memory T cells in mice lacking mature B cells (muMT …

The neglected Chagas disease (CD) is caused by the protozoan parasite Trypanosoma
cruzi. Despite CD dispersion throughout the world, it prevails in tropical areas affecting …

Background Chronic chagasic cardiomyopathy (CCC), the main clinical sign of Chagas
disease, is associated with systemic CD8+ T-cell abnormalities and CD8-enriched …

One of the main challenges in cancer research is the development of vaccines that induce
effective and long-lived protective immunity against tumors. Significant progress has been …

Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is a major public
health problem in most of Latin America. A key priority is the development of new treatments …