Recent functional insights into the role of (p) ppGpp in bacterial physiology
The alarmones guanosine tetraphosphate and guanosine pentaphosphate (collectively
referred to as (p) ppGpp) are involved in regulating growth and several different stress …
referred to as (p) ppGpp) are involved in regulating growth and several different stress …
Regulatory themes and variations by the stress-signaling nucleotide alarmones (p) ppGpp in bacteria
Bacterial stress-signaling alarmones are important components of a protective network
against diverse stresses such as nutrient starvation and antibiotic assault. pppGpp and …
against diverse stresses such as nutrient starvation and antibiotic assault. pppGpp and …
(p) ppGpp: magic modulators of bacterial physiology and metabolism
W Steinchen, V Zegarra, G Bange - Frontiers in Microbiology, 2020 - frontiersin.org
When bacteria experience growth-limiting environmental conditions, the synthesis of the
hyperphosphorylated guanosine derivatives (p) ppGpp is induced by enzymes of the …
hyperphosphorylated guanosine derivatives (p) ppGpp is induced by enzymes of the …
The magic dance of the alarmones (p) ppGpp
W Steinchen, G Bange - Molecular microbiology, 2016 - Wiley Online Library
The alarmones (p) ppGpp are important second messengers that orchestrate pleiotropic
adaptations of bacteria and plant chloroplasts in response to starvation and stress. Here, we …
adaptations of bacteria and plant chloroplasts in response to starvation and stress. Here, we …
Diversity in (p) ppGpp metabolism and effectors
Highlights•(p) ppGpp metabolic enzymes sense diverse stresses.•(p) ppGpp regulates
transcription initiation by targeting RNAP or GTP levels.•(p) ppGpp controls replication …
transcription initiation by targeting RNAP or GTP levels.•(p) ppGpp controls replication …
(p) ppGpp and the stringent response: an emerging threat to antibiotic therapy
JK Hobbs, AB Boraston - ACS infectious diseases, 2019 - ACS Publications
In 1969, Cashel and Gallant first observed the presence of (p) ppGpp—the signaling
molecule of the stringent response—in starved bacterial cells. Fifty years later,(p) ppGpp and …
molecule of the stringent response—in starved bacterial cells. Fifty years later,(p) ppGpp and …
Many means to a common end: the intricacies of (p) ppGpp metabolism and its control of bacterial homeostasis
In nearly all bacterial species examined so far, amino acid starvation triggers the rapid
accumulation of the nucleotide second messenger (p) ppGpp, the effector of the stringent …
accumulation of the nucleotide second messenger (p) ppGpp, the effector of the stringent …
The alarmones (p) ppGpp directly regulate translation initiation during entry into quiescence
S Diez, J Ryu, K Caban… - Proceedings of the …, 2020 - National Acad Sciences
Many bacteria exist in a state of metabolic quiescence where energy consumption must be
minimized so as to maximize available resources over a potentially extended period of time …
minimized so as to maximize available resources over a potentially extended period of time …
The PAMP c-di-AMP is essential for Listeria monocytogenes growth in rich but not minimal media due to a toxic increase in (p) ppGpp
AT Whiteley, AJ Pollock, DA Portnoy - Cell host & microbe, 2015 - cell.com
Cyclic di-adenosine monophosphate (c-di-AMP) is a widely distributed second messenger
that appears to be essential in multiple bacterial species, including the Gram-positive …
that appears to be essential in multiple bacterial species, including the Gram-positive …
Two P or not two P: understanding regulation by the bacterial second messengers (p) ppGpp
G Bange, DE Brodersen, A Liuzzi… - Annual Review of …, 2021 - annualreviews.org
Under stressful growth conditions and nutrient starvation, bacteria adapt by synthesizing
signaling molecules that profoundly reprogram cellular physiology. At the onset of this …
signaling molecules that profoundly reprogram cellular physiology. At the onset of this …