Mitochondrial metabolism plays a central role in the regulation of hematopoietic stem cell
(HSC) biology. Mitochondrial fatty acid oxidation (FAO) is pivotal in controlling HSC self …

Many tissues and organ systems have intrinsic regeneration capabilities that are largely
driven and maintained by tissue-resident stem cell populations. In recent years, growing …

Aging of hematopoietic stem cells (HSCs) is accompanied by impaired self-renewal ability,
myeloid skewing, immunodeficiencies and increased susceptibility to malignancies …

YTHDC1, a reader of N6-methyladenosine (m6A) modifications on RNA, is posited to exert
significant influence over RNA metabolism. Despite its recognized importance, the precise …

Hematopoietic stem cells (HSCs) reside at the top of the hematopoietic hierarchy, exhibiting
a unique capacity to self-renew and differentiate into all blood cells throughout the lifetime …

Hematopoietic stem cells (HSC) are primarily dormant in a cell-cycle quiescence state to
preserve their self-renewal capacity and long-term maintenance. How HSC maintain the …

Hematopoietic stem and progenitor cell (HSPC) transplantation serves as a curative therapy
for many benign and malignant hematopoietic disorders and as a platform for gene therapy …

Hematopoietic stem cells (HSCs) and leukemic stem cells (LSCs) are crucial for ensuring
hematopoietic homeostasis and driving leukemia progression, respectively. Recent …

Organ regeneration and manufacturing are promising new research directions in the life
sciences. Stem cells and their niches, which exist in most adult organs, play a central role in …

Abstract Background Ginsenoside Rh2 (G-Rh2), a steroidal compound extracted from roots
of ginseng, has been extensively studied in tumor therapy. However, its specific regulatory …