Natural phenolic compounds and derivatives as potential antimalarial agents

L Mamede, A Ledoux, O Jansen, M Frédérich - Planta medica, 2020 - thieme-connect.com
Malaria is a parasitic disease endemic to tropical and subtropical regions responsible for
hundreds of millions of clinical cases and hundreds of thousands of deaths yearly. Its agent …

In vitro and in vivo antimalarial activity and chemical profiling of sugarcane leaves

JE Okokon, R Mobley, UA Edem, AI Bassey… - Scientific Reports, 2022 - nature.com
Abstract Saccharum officinarum Linn.(sugarcane, Family-Poaceae) is employed in Ibibio
traditional medicine for the treatment of various infections and diseases such as malaria. We …

The synthesis and evaluation of thymoquinone analogues as anti-ovarian cancer and antimalarial agents

OR Johnson-Ajinwo, I Ullah, H Mbye… - Bioorganic & Medicinal …, 2018 - Elsevier
Abstract Thymoquinone (TQ), 2-isopropyl-5-methyl-1, 4-benzoquinone, a natural product
isolated from Nigella sativa L., has previously been demonstrated to exhibit antiproliferative …

Natural products as sources of antimalarial drugs: ethnobotanical and ethnopharmacological studies

OS Oladeji, AP Oluyori, DT Bankole, TY Afolabi - Scientifica, 2020 - Wiley Online Library
Ethnopharmacological Relevance. Malaria is one of the lethal diseases of man, contributing
to about 17 million deaths annually, leading to sociocultural, economic, and health …

[HTML][HTML] In vivo antihyperglycaemic and antihyperlipidemic activities and chemical constituents of Solanum anomalum

JE Okokon, IC Etuk, PS Thomas, FP Drijfhout… - Biomedicine & …, 2022 - Elsevier
Solanum anomalum is a plant used ethnomedically for the treatment of diabetes. The study
was aimed to validate ethnomedical claims in rat model and identify the likely antidiabetic …

Antibacterial and antibiotic potentiating activities of tropical marine sponge extracts

R Beesoo, R Bhagooli, VS Neergheen-Bhujun… - … and Physiology Part C …, 2017 - Elsevier
Increasing prevalence of antibiotic resistance has led research to focus on discovering new
antimicrobial agents derived from the marine biome. Although ample studies have …

Overview of natural Antiplasmodials from the last decade to inspire medicinal chemistry

G Degotte, B Pirotte, P Francotte… - Current Medicinal …, 2021 - ingentaconnect.com
Background: Despite major advances in the fight against this parasitic disease, malaria
remained a major cause of concern in 2021. This infection, mainly due to Plasmodium …

Antimalarial activities of a therapeutic combination of Azadirachta indica, Mangifera indica and Morinda lucida leaves: a molecular view of its activity on Plasmodium …

SI Abdulai, AA Ishola, CO Bewaji - Acta Parasitologica, 2023 - Springer
Background The search for new antimalarial drugs remains elusive prompting research into
antimalarial combinations from medicinal plants due to their cheapness, efficacy and …

Two New Cytotoxic Sesquiterpene-Amino Acid Conjugates and a Coumarin-Glucoside from Crossostephium chinense

Z Wang, BYA Chitama, K Suganuma, Y Yamano… - Molecules, 2023 - mdpi.com
The Asteraceae family is a promising source of bioactive compounds, such as the famous
Asteraceae plants Tanacetum cinerariifolium (pyrethrin) and Artemisia annua (artemisinin) …

Pluripharmacological potential of Mascarene endemic plant leaf extracts

N Rummun, B Payne, AB van Staden, D Twilley… - Biocatalysis and …, 2023 - Elsevier
Tropical forests of the islands of the West Indian Ocean region, have a rich and diverse
collection of unique plants containing a multitude of chemical scaffolds that can potentially …