Airway metabolic profiling during Streptococcus pneumoniae infection identifies branched chain amino acids as signatures of upper airway colonisation

AE Green, S Pottenger, MS Monshi, TE Barton… - PLoS …, 2023 - journals.plos.org
Streptococcus pneumoniae is a leading cause of community-acquired pneumonia and
bacteraemia and is capable of remarkable phenotypic plasticity, responding rapidly to …

Role of Staphylococcus aureus formate metabolism during prosthetic joint infection

BP Bertrand, CE Heim, SC West… - Infection and …, 2022 - Am Soc Microbiol
Biofilms are bacterial communities characterized by antibiotic tolerance. Staphylococcus
aureus is a leading cause of biofilm infections on medical devices, including prosthetic …

Pyruvate-formate lyase and beyond

X Zhang, W Ye, W Jiang, Y Gu - Journal of Environmental Chemical …, 2024 - Elsevier
Pyruvate-formate lyases (PFLs) are crucial catalysts that employ both a core enzyme and an
activating enzyme to facilitate the conversion of pyruvate to formate and acetyl-CoA, as well …

Rgg-Shp regulators are important for pneumococcal colonization and invasion through their effect on mannose utilization and capsule synthesis

X Zhi, IT Abdullah, O Gazioglu, I Manzoor, S Shafeeq… - Scientific Reports, 2018 - nature.com
Microbes communicate with each other by using quorum sensing (QS) systems and
modulate their collective 'behavior'for in-host colonization and virulence, biofilm formation …

Role of the pyruvate metabolic network on carbohydrate metabolism and virulence in Streptococcus pneumoniae

H Echlin, M Frank, C Rock, JW Rosch - Molecular microbiology, 2020 - Wiley Online Library
Streptococcus pneumoniae is a major human pathogen that must adapt to unique nutritional
environments in several host niches. The pneumococcus can metabolize a range of …

[HTML][HTML] Functional assessment of microbial superoxide dismutase isozymes suggests a differential role for each isozyme

H Najmuldeen, R Alghamdi, F Alghofaili… - Free radical biology and …, 2019 - Elsevier
Microbes can have multiple enzymes that are able to catalyse the same enzymatic reactions
but may differ in structure. These are known as isozymes. It is assumed that isozymes have …

Carbon source-dependent reprogramming of anaerobic metabolism in Staphylococcus aureus

A Troitzsch, VV Loi, K Methling, D Zühlke… - Journal of …, 2021 - Am Soc Microbiol
To be a successful pathogen, Staphylococcus aureus has to adapt its metabolism to the
typically oxygen-and glucose-limited environment of the host. Under fermenting conditions …

Time-resolved transcriptomic and proteomic profiling of Heyndrickxia coagulans during NaOH-buffered L-lactic acid production

X Huang, W Tian, X Wang, J Qin - Frontiers in Microbiology, 2023 - frontiersin.org
The L-lactic acid (L-LA) fermentation process, based on sodium hydroxide neutralization,
demonstrates environmental friendliness during product extraction. However, lactate …

A multiomics analysis of direct interkingdom dynamics between influenza A virus and Streptococcus pneumoniae uncovers host-independent changes to bacterial …

MP Platt, YH Lin, T Penix, R Wiscovitch-Russo… - Plos …, 2022 - journals.plos.org
Background For almost a century, it has been recognized that influenza A virus (IAV)
infection can promote the development of secondary bacterial infections (SBI) mainly …

A novel streptococcal cell–cell communication peptide promotes pneumococcal virulence and biofilm formation

RA Cuevas, R Eutsey, A Kadam… - Molecular …, 2017 - Wiley Online Library
Streptococcus pneumoniae (pneumococcus) is a major human pathogen. It is a common
colonizer of the human respiratory track, where it utilizes cell–cell communication systems to …