I Shimada, T Ueda, Y Kofuku, MT Eddy… - Nature Reviews Drug …, 2019 - nature.com
The 826 G protein-coupled receptors (GPCRs) in the human proteome regulate key physiological processes and thus have long been attractive drug targets. With the crystal …
TK Heiss, RS Dorn, JA Prescher - Chemical reviews, 2021 - ACS Publications
Bioorthogonal phosphines were introduced in the context of the Staudinger ligation over 20 years ago. Since that time, phosphine probes have been used in myriad applications to tag …
The ability to sense external stimuli and dynamically respond lies at the core of cellular homeostasis. G protein-coupled receptors (GPCRs), the largest family of membrane proteins …
H Tian, A Furstenberg, T Huber - Chemical reviews, 2017 - ACS Publications
The superfamily of G protein-coupled receptors (GPCRs) mediates a wide range of physiological responses and serves as an important category of drug targets. Earlier …
M Damian, S Mary, M Maingot… - Proceedings of the …, 2015 - National Acad Sciences
How G protein-coupled receptor conformational dynamics control G protein coupling to trigger signaling is a key but still open question. We addressed this question with a model …
Exciting new technological developments have pushed the boundaries of structural biology, and have enabled studies of biological macromolecules and assemblies that would have …
Transfer of information across membranes is fundamental to the function of all organisms and is primarily initiated by transmembrane receptors. For many receptors, how ligand …
S Zhu, M Riou, CA Yao, S Carvalho… - Proceedings of the …, 2014 - National Acad Sciences
Reprogramming receptors to artificially respond to light has strong potential for molecular studies and interrogation of biological functions. Here, we design a light-controlled …
BWH Liauw, A Foroutan, MR Schamber, W Lu… - Elife, 2022 - elifesciences.org
Activation of G protein-coupled receptors (GPCRs) is an allosteric process. It involves conformational coupling between the orthosteric ligand binding site and the G protein …