While the Staudinger reaction has first been described a hundred years ago in 1919, the
ligation reaction became one of the most important and efficient bioconjugation techniques …

The 826 G protein-coupled receptors (GPCRs) in the human proteome regulate key
physiological processes and thus have long been attractive drug targets. With the crystal …

Bioorthogonal phosphines were introduced in the context of the Staudinger ligation over 20
years ago. Since that time, phosphine probes have been used in myriad applications to tag …

The ability to sense external stimuli and dynamically respond lies at the core of cellular
homeostasis. G protein-coupled receptors (GPCRs), the largest family of membrane proteins …

The superfamily of G protein-coupled receptors (GPCRs) mediates a wide range of
physiological responses and serves as an important category of drug targets. Earlier …

How G protein-coupled receptor conformational dynamics control G protein coupling to
trigger signaling is a key but still open question. We addressed this question with a model …

Exciting new technological developments have pushed the boundaries of structural biology,
and have enabled studies of biological macromolecules and assemblies that would have …

Transfer of information across membranes is fundamental to the function of all organisms
and is primarily initiated by transmembrane receptors. For many receptors, how ligand …

Reprogramming receptors to artificially respond to light has strong potential for molecular
studies and interrogation of biological functions. Here, we design a light-controlled …

Activation of G protein-coupled receptors (GPCRs) is an allosteric process. It involves
conformational coupling between the orthosteric ligand binding site and the G protein …