G-protein-coupled receptors (GPCRs) are the largest family of cell surface signaling
receptors known to play a crucial role in various physiological functions, including tumor …

G protein-coupled receptors (GPCRs) belong to a superfamily of cell surface signalling
proteins that have a pivotal role in many physiological functions and in multiple diseases …

Invasion is a defining hallmark of glioblastoma multiforme, just as metastasis characterizes
other high-grade tumors. Glial tumors invariably recur due to the regrowth of invasive cells …

Despite considerable amount of research, the poor prognosis of patients diagnosed with
glioblastoma multiforme (GBM) critically needs new drug development to improve clinical …

The two lysophospholipids (LPs) lysophosphatidic acid and sphingosine 1-phosphate (S1P)
regulate diverse biological processes. Over the past decade, it has become clear that …

Sphingosine-1-phosphate is a potent sphingolipid mediator of diverse processes important
for brain tumors, including cell growth, survival, migration, invasion, and angiogenesis …

Abstract Sphingosine 1‐phosphate (S1P) is accumulated in lipoproteins, especially high‐
density lipoprotein (HDL), in plasma. However, it remains uncharacterized how extracellular …

Background Previous studies identified the human nonmetastatic gene 23 (NME1, hereafter
Nm23-H1) as the first metastasis suppressor gene. An inverse relationship between Nm23 …

Background Colorectal cancer is a common disease that involves genetic alterations, such
as inactivation of tumour suppressor genes and activation of oncogenes. Among them are …

While normal angiogenesis is critical for development and tissue growth, pathological
angiogenesis is important for the growth and spread of cancers by supplying nutrients and …