Autophagy is a cellular degradative pathway that plays diverse roles in maintaining cellular
homeostasis. Cellular stress caused by starvation, organelle damage, or proteotoxic …

Autophagy is a conserved process in which the cytosolic materials are degraded and
eventually recycled for cellular metabolism to maintain homeostasis. The dichotomous role …

Autophagy has been of novel interest since it was first demonstrated to have effect in
Burkitt's lymphoma. Since that time, the autophagy agents chloroquine and …

Cytotoxic drugs remain the first-line option for cancer therapy but the development of drug-
resistance by tumor cells represents a primary obstacle for successful chemotherapy …

Autophagy is a tightly regulated catabolic process that facilitates nutrient recycling from
damaged organelles and other cellular components through lysosomal degradation …

Background. Diabetes mellitus is a chronic metabolic disorder characterized by persistent
hyperglycemia. It affects millions of people globally. In spite of many antidiabetic drugs that …

Macroautophagy (herein referred to as autophagy) is a complex catabolic process
characterized by the formation of double-membrane vesicles called autophagosomes …

Chloroquine (CQ) and hydroxychloroquine (HCQ) are derivatives of the heterocyclic
aromatic compound quinoline. These economical compounds have been used as …

Cancer cells use autophagy for growth, survival, and cytoprotection from chemotherapy.
Therefore, autophagy inhibitors appear to be good candidates for cancer treatment. Our …

Autophagy is a process of eliminating damaged or unnecessary proteins and organelles,
thereby maintaining intracellular homeostasis. Deregulation of autophagy is associated with …