Src homology 2 (SH2)-containing protein tyrosine phosphatase 2 (SHP2), encoded by the
human PTPN11 gene, is a ubiquitously expressed protein tyrosine phosphatase (PTP) that …

Membrane microdomains denoted commonly as lipid rafts (or membrane rafts) have been
implicated in T-cell receptor (TCR), and more generally immunoreceptor, signaling for over …

Carefully orchestrated intercellular communication is an essential prerequisite for the
development of multicellular organisms. In recent years, tunneling nanotubes (TNT) have …

Muscle cells have different phenotypes adapted to different usage, and can be grossly
divided into fast/glycolytic and slow/oxidative types. While most muscles contain a mixture of …

Posttranscriptional regulation has emerged as a driver for leukemia development and an
avenue for therapeutic targeting. Among posttranscriptional processes, alternative …

LST1 is a small adaptor protein expressed in leukocytes of myeloid lineage. Due to the
binding to protein tyrosine phosphatases SHP1 and SHP2 it was thought to have negative …

Transmembrane adaptor proteins (TRAPs) are structurally related proteins that have no
enzymatic function, but enable inducible recruitment of effector molecules to the plasma …

Myeloid malignancies, including myelodysplastic syndromes, chronic myelomonocytic
leukemia, and acute myeloid leukemia, are characterized by abnormal proliferation and …

The plasma membrane contains diverse and specialized membrane domains, which include
tetraspanin-enriched domains (TEMs) and transmembrane adaptor protein (TRAP)-enriched …

Toll‐like receptor (TLR) signaling relies on Toll/interleukin‐1 receptor homology (TIR)
domain‐containing adaptor proteins that recruit downstream signaling molecules to …