Cholesterol is an essential substance involved in many functions, such as maintaining cell
membranes, manufacturing vitamin D on surface of the skin, producing hormones, and …

Dietary sphingomyelin (SM) is hydrolyzed by intestinal alkaline sphingomyelinase and
neutral ceramidase to sphingosine, which is absorbed and converted to palmitic acid and …

A new member of the lipase gene family, initially termed endothelial lipase (gene
nomenclature, LIPG; protein, EL), is expressed in a variety of different tissues, suggesting a …

High-density lipoproteins (HDL) play a major protective role against the development of
coronary artery disease. Phospholipid transfer protein (PLTP) is a main factor regulating the …

Tissue arachidonic acid (AA) pools originate from the diet, and from hepatic and
extrahepatic desaturation-elongation of dietary linoleic acid (LA). This review summarizes …

Bile acids facilitate the absorption of dietary lipids and fat-soluble vitamins and are
physiological ligands for the farnesoid X-activated receptor (FXR), a member of the nuclear …

Endotoxemia is associated with rapid and marked declines in serum levels of LDL and HDL
by unknown mechanisms. Six normal volunteers received a single, small intravenous (iv) …

Liver X receptors (LXR) belong to the nuclear receptor superfamily that can regulate
important lipid metabolic pathways. The plasma phospholipid transfer protein (PLTP) is …

High-density lipoprotein (HDL) particles have experienced a turbulent decade of falling from
grace with widespread demotion from the most-sought-after therapeutic target to reverse …

Epidemiological studies point to an inverse relationship between high-density lipoprotein
(HDL) levels and the risk of coronary artery disease (CAD). 1-5 Clinical trials such as the …