Kjær, Michael. Role of Extracellular Matrix in Adaptation of Tendon and Skeletal Muscle to
Mechanical Loading. Physiol Rev 84: 649–698, 2004; 10.1152/physrev. 00031.2003.—The …

The extracellular matrix is an integral and dynamic component of all tissues.
Macromolecular compositions and structural architectures of the matrix are tissue-specific …

Elastic fibres are essential extracellular matrix macromolecules comprising an elastin core
surrounded by a mantle of fibrillin-rich microfibrils. They endow connective tissues such as …

FBN1 encodes the gene for fibrillin-1, a structural macromolecule that polymerizes into
microfibrils. Fibrillin microfibrils are morphologically distinctive fibrils, present in all …

▪ Abstract Electron tomography (ET) is uniquely suited to obtain three-dimensional
reconstructions of pleomorphic structures, such as cells, organelles or supramolecular …

Latent transforming growth factor β-binding protein 1 (LTBP-1) targets latent complexes of
transforming growth factor β to the extracellular matrix, where the latent cytokine is …

The ability of elastic tissues to deform under physiological forces and to subsequently
release stored energy to drive passive recoil is vital to the function of many dynamic tissues …

Marfan syndrome is a connective tissue disorder caused by mutations in the gene encoding
fibrillin-1 (FBN1). A dominant-negative mechanism has been inferred based upon dominant …

Marfan syndrome (MFS), a relatively common autosomal dominant hereditary disorder of
connective tissue with prominent manifestations in the skeletal, ocular, and cardiovascular …

Fibrillin microfibrils are extensible polymers that endow connective tissues with long-range
elasticity and have widespread distributions in both elastic and non-elastic tissues. They act …