Mitochondrial energetic adaptations encompass a plethora of conserved processes that
maintain cell and organismal fitness and survival in the changing environment by adjusting …

Biogenesis of mitochondria requires the import of approximately 1,000 different precursor
proteins into and across the mitochondrial membranes. Mitochondria exhibit a wide variety …

Over the past decade, it has become clear that lipid homeostasis is central to cellular
metabolism. Lipids are particularly abundant in the central nervous system (CNS) where …

Mitochondria are dynamic organelles that have essential metabolic and regulatory functions.
Earlier studies using electron microscopy (EM) revealed an immense diversity in the …

Despite clinical and scientific advancements, heart failure is the major cause of morbidity
and mortality worldwide. Both mitochondrial dysfunction and inflammation contribute to the …

Endoplasmic reticulum (ER)-mitochondria contacts are critical for the regulation of lipid
transport, synthesis, and metabolism. However, the molecular mechanism and physiological …

Significance: Mitochondrial (mt) reticulum network in the cell possesses amazing
ultramorphology of parallel lamellar cristae, formed by the invaginated inner mitochondrial …

Simple Summary Mitochondria possess an outer and inner membrane. The part of the inner
membrane parallel to the outer membrane is termed the inner boundary membrane, while …

Mitochondria play a key role in cellular signalling, metabolism and energetics. Proper
architecture and remodelling of the inner mitochondrial membrane are essential for efficient …

APOO/MIC26 is a subunit of the MICOS complex required for mitochondrial cristae
morphology and function. Here, we report a novel variant of the APOO/MIC26 gene that …