Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and
represents a high-grade neoplasm of skeletal myoblast-like cells. Decades of clinical and …

Emerging evidence suggests that the signalling of the Receptor for Advanced Glycation End
products (RAGE) is critical for skeletal muscle physiology controlling both the activity of …

Background Cachexia, a multifactorial syndrome affecting more than 50% of patients with
advanced cancer and responsible for~ 20% of cancer‐associated deaths, is still a poorly …

PTEN is a tumour suppressor frequently mutated in many types of cancers. Here we show
that targeted disruption of PTEN leads to neoplastic transformation of human neural stem …

Scavenger receptors constitute a large family of evolutionally conserved protein molecules
that are structurally and functionally diverse. Although scavenger receptors were originally …

Rhabdomyosarcoma represents about 50% of soft-tissue sarcomas and 10% of malignant
solid tumors in childhood. Embryonal rhabdomyosarcoma (ERMS) is the most frequent …

Eph receptor tyrosine kinases control cell-cell interactions during normal and oncogenic
development, and are implicated in a range of processes including angiogenesis, stem cell …

Rhabdomyosarcoma (RMS) is the most common malignant soft tissue tumour in children
and adolescents. Histologically RMS resembles developing fetal striated skeletal muscle …

Impairment of the prominent tumor suppressor p53, well known for its canonical role as the
“guardian of the genome”, is found in almost half of human cancers. More recently, p53 has …

Embryonal rhabdomyosarcoma (ERMS) is the most common soft tissue cancer in children.
The prognosis of patients with relapsed or metastatic disease remains poor. ERMS …