[HTML][HTML] Epidemiology of non-alcoholic and alcoholic fatty liver diseases

S Mitra, A De, A Chowdhury - Translational gastroenterology and …, 2020 - ncbi.nlm.nih.gov
Liver diseases are fast emerging as global health priorities. Fatty liver is described in the
setting of non-alcoholic fatty liver disease (NAFLD) as well as alcoholic liver disease (ALD) …

The role of the NLRP3 inflammasome and programmed cell death in acute liver injury

C Yu, P Chen, L Miao, G Di - International Journal of Molecular Sciences, 2023 - mdpi.com
Acute liver injury (ALI) is a globally important public health issue that, when severe, rapidly
progresses to acute liver failure, seriously compromising the life safety of patients. The …

Targeting heme oxygenase-1 by quercetin ameliorates alcohol-induced acute liver injury via inhibiting NLRP3 inflammasome activation

S Liu, L Tian, G Chai, B Wen, B Wang - Food & function, 2018 - pubs.rsc.org
Alcoholic hepatitis (AH) is characterized by inflammation and necrosis of liver tissue caused
by excessive alcohol consumption and it even causes organ failure sometimes, in which …

Natural history of histologically proven alcohol-related liver disease: a systematic review

R Parker, GP Aithal, U Becker, D Gleeson… - Journal of …, 2019 - Elsevier
Background & Aims To date, studies into the natural history of alcohol-related liver disease
(ALD) have lacked long-term follow-up, large numbers of participants, or both. We performed …

Epithelial splicing regulatory protein 2–mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis

J Hyun, Z Sun, AR Ahmadi, S Bangru… - The Journal of …, 2020 - Am Soc Clin Investig
Severe alcoholic hepatitis (SAH) is a deadly liver disease without an effective medical
therapy. Although SAH mortality is known to correlate with hepatic accumulation of immature …

Advances in the understanding and management of alcohol-related liver disease

M Thursz, A Lingford-Hughes - bmj, 2023 - bmj.com
Alcohol-related liver disease (ALD) is a major cause of liver-related morbidity and mortality.
Epidemiological trends indicate recent and predicted increases in the burden of disease …

Obesity in acute alcoholic hepatitis increases morbidity and mortality

R Parker, SJ Kim, GY Im, J Nahas, B Dhesi, N Vergis… - …, 2019 - thelancet.com
Background Alcohol and obesity synergise to increase the risk of liver-related mortality. We
examined the influence of adiposity on clinical outcomes in alcoholic hepatitis (AH) and the …

Trajectory of serum bilirubin predicts spontaneous recovery in a real-world cohort of patients with alcoholic hepatitis

R Parker, J Cabezas, J Altamirano, JP Arab… - Clinical …, 2022 - Elsevier
Background and aims Alcoholic hepatitis (AH) is a severe condition with poor short-term
prognosis. Specific treatment with corticosteroids slightly improves short-term survival but is …

Systematic review with meta‐analysis: high mortality in patients with non‐severe alcoholic hepatitis

K Bennett, DG Enki, M Thursz… - Alimentary …, 2019 - Wiley Online Library
Background Alcoholic hepatitis is a serious complication of alcohol misuse. Severe alcoholic
hepatitis with its high mortality, has been investigated in detail but 'nonsevere alcoholic …

Adding inflammatory markers and refining national Institute on alcohol Abuse and alcoholism criteria improve diagnostic accuracy for alcohol-associated hepatitis

E Avitabile, A Díaz, C Montironi… - Clinical …, 2023 - Elsevier
Background & Aims Although histology is considered the gold standard for diagnosis of
alcohol-associated hepatitis (AH), it is not required for entry into therapeutic studies if …