Epidemiology of multiple sclerosis: from risk factors to prevention—an update

A Ascherio, KL Munger - Seminars in neurology, 2016 - thieme-connect.com
Although genetic susceptibility explains the clustering of multiple sclerosis (MS) within
families and the sharp decline in risk with increasing genetic distance, it cannot fully explain …

Real-time PCR in clinical microbiology: applications for routine laboratory testing

MJ Espy, JR Uhl, LM Sloan… - Clinical microbiology …, 2006 - Am Soc Microbiol
Real-time PCR has revolutionized the way clinical microbiology laboratories diagnose many
human microbial infections. This testing method combines PCR chemistry with fluorescent …

Environmental risk factors for multiple sclerosis. Part I: the role of infection

A Ascherio, KL Munger - Annals of neurology, 2007 - Wiley Online Library
Although genetic susceptibility explains the clustering of multiple sclerosis (MS) cases within
families and the sharp decline in risk with increasing genetic distance, it cannot fully explain …

Primary infection with the Epstein‐Barr virus and risk of multiple sclerosis

LI Levin, KL Munger, EJ O'reilly, KI Falk… - Annals of …, 2010 - Wiley Online Library
To determine whether multiple sclerosis (MS) risk increases following primary infection with
the Epstein‐Barr virus (EBV), we conducted a nested case‐control study including 305 …

Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain

B Serafini, B Rosicarelli, D Franciotta… - The Journal of …, 2007 - rupress.org
Epstein-Barr virus (EBV), a ubiquitous B-lymphotropic herpesvirus, has been associated
with multiple sclerosis (MS), an inflammatory disease of the central nervous system (CNS) …

The epidemiology of multiple sclerosis: insights to disease pathogenesis

DS Goodin - Handbook of clinical neurology, 2014 - Elsevier
The purpose of studying the epidemiology of multiple sclerosis (MS) is twofold. First, it is
important to understand clearly the natural history of the illness in order to assist patients in …

The initiation and prevention of multiple sclerosis

A Ascherio, KL Munger, JD Lünemann - Nature Reviews Neurology, 2012 - nature.com
Although strong genetic determinants of multiple sclerosis (MS) exist, the findings of
migration studies support a role for environmental factors in this disease. Through rigorous …

Infectious mononucleosis and risk for multiple sclerosis: a meta‐analysis

EL Thacker, F Mirzaei, A Ascherio - Annals of neurology, 2006 - Wiley Online Library
Objective To characterize the association between infectious mononucleosis (IM), a frequent
clinical manifestation of primary Epstein–Barr virus infection after childhood, and the risk for …

Environmental risk factors in multiple sclerosis aetiology

RA Marrie - The Lancet Neurology, 2004 - thelancet.com
The epidemiology of multiple sclerosis (MS) has been intensively studied. It is
conceptualised as a complex disease in which genetic and environmental factors act …

Multiple sclerosis risk factors and pathogenesis

B Nourbakhsh, EM Mowry - CONTINUUM: Lifelong Learning in …, 2019 - journals.lww.com
PURPOSE OF REVIEW This article summarizes recent advances in the identification of
genetic and environmental factors that affect the risk of developing multiple sclerosis (MS) …