Recently, the interest in using nucleic acids for therapeutic applications has been
increasing. DNA molecules can be manipulated to express a gene of interest for gene …

Electroporation (EP) allows for the transport of molecules into the cytoplasm with significant
effectiveness by forming transient pores in the cell membrane using electric pulses. This can …

Objectives This study investigated whether exosomes from LPS pretreated bone marrow
mesenchymal stem cells (LPS pre-MSCs) could prolong skin graft survival. Methods The …

Gene immunotherapy has become an important approach in the treatment of cancer. One
example is the introduction of genes encoding immunostimulatory cytokines, such as …

Immunotherapeutic drugs are promising medicines for cancer treatment. A potential
candidate for immunotherapy is interleukin-12 (IL-12), a cytokine well known for its ability to …

Dendritic cells (DCs) constitute a distinct type of immune cell found within tumors, serving a
central role in mediating tumor antigen-specific immunity against cancer cells. Frequently …

Skin, the largest organ in the body, provides a passive physical barrier against infection and
contains elements of the innate and adaptive immune systems. Skin consists of various …

Simple Summary Immunotherapy has been evolving rapidly in recent years. As a key
component of the immune system, cytokines play essential roles not only in immune …

The exact mechanisms of nucleic acid (NA) delivery with gene electrotransfer (GET) are still
unknown, which represents a limitation for its broader use. Further, not knowing the effects …

Cancer is characterized by unlimited proliferation and metastasis, and traditional therapeutic
strategies usually result in the acquisition of drug resistance, thus highlighting the need for …