Defects in membrane trafficking are hallmarks of neurodegeneration. Rab GTPases are key
regulators of membrane trafficking. Alterations of Rab GTPases, or the membrane …

Vesicular/membrane trafficking essentially regulates the compartmentalization and
abundance of proteins within the cells and contributes in many signalling pathways. This …

The ATP-dependent proton pump V-ATPase ensures low intralysosomal pH, which is
essential for lysosomal hydrolase activity. Based on studies with the V-ATPase inhibitor …

Recent genome-wide association studies have linked common variants in the human
genome to Parkinson's disease (PD) risk. Here we show that the consequences of variants …

Parkinson's disease (PD) is characterized pathologically by intraneuronal inclusions called
Lewy bodies, largely comprised of α-synuclein. Multiplication of the α-synuclein gene locus …

Summary The Rab GTPases recruit peripheral membrane proteins to intracellular
organelles. These Rab effectors typically mediate the motility of organelles and vesicles and …

We report a new approach to cisplatin storage and release using porous hollow
nanoparticles (PHNPs) of Fe3O4. We prepared the PHNPs by controlled oxidation of Fe NPs …

Wnt signaling plays critical roles during synaptic development and plasticity. However, the
mechanisms by which Wnts are released and travel to target cells are unresolved. During …

A non-coding hexanucleotide repeat expansion in intron 1 of the C9orf72 gene is the most
common cause of amyotrophic lateral sclerosis and frontotemporal dementia (C9ALS/FTD) …

Since its debut in the biomedical research fields in 1981, zebrafish have been used as a
vertebrate model organism in more than 40,000 biomedical research studies. Especially …