Hemolysis is a fundamental feature of sickle cell anemia that contributes to its
pathophysiology and phenotypic variability. Decompartmentalized hemoglobin, arginase 1 …

Sickle cell disease (SCD) is a widespread disease caused by a mutation in the beta-globin
gene that leads to the production of abnormal hemoglobin called hemoglobin S. The …

Sickle cell disease (SCD) is a hematological disorder leading to blood vessel occlusion
accompanied by painful episodes and even death. Red blood cells (RBCs) of SCD patients …

Although the root cause of sickle cell disease is the polymerization of hemoglobin S (HbS) to
form fibers that make red cells less flexible, most drugs currently being assessed in clinical …

We present a sheathless, microfluidic imaging flow cytometer that incorporates stroboscopic
illumination for blur-free fluorescence detection at ultra-high analytical throughput. The …

We developed a microfluidics-based model to quantify cell-level processes modulating the
pathophysiology of sickle cell disease (SCD). This in vitro model enabled quantitative …

Functional studies have shown that the oxygenation state of the erythrocyte regulates many
important pathways, including glucose metabolism, membrane mechanical stability, and …

In sickle cell disease (SCD), sickle hemoglobin (HbS) polymerizes upon deoxygenation,
resulting in sickling of red blood cells (RBCs). These sickled RBCs have strongly reduced …

Hemoglobin (Hb) abnormalities, such as thalassemia and structural Hb variants, are among
the most prevalent inherited diseases and are associated with significant mortality and …

Cellular heterogeneity is of significance in cell-based assays for life science, biomedicine
and clinical diagnostics. Electrical impedance sensing technology has become a powerful …