The hypothesis that rapid eye movement (REM) sleep disturbances are the hallmark of
posttraumatic stress disorder (PTSD), proposed by Ross and colleagues in 1989, has …

According to the two-process model of sleep regulation, the timing and structure of sleep are
determined by the interaction of a homeostatic and a circadian process. The original …

Wearable sensors are currently being used to manage fatigue in professional athletics,
transportation and mining industries. In manufacturing, physical fatigue is a challenging …

Many immune parameters show systematic fluctuations over the 24‐h day in human blood.
Circulating naive T‐cells and production of proinflammatory cytokines, like interleukin‐12 (IL …

EEG slow-wave activity (SWA; spectral power in the 0.75–4.5 Hz band) is a function of the
duration of prior waking and, thereby, an indicator of sleep homeostasis. We present a …

Patients with pathologically increased daytime sleepiness and fatigue have elevated levels
of circulating interleukin-6 (IL-6). The latter is an inflammatory cytokine, which causes …

Sleep is under homeostatic control, whereby increasing wakefulness generates sleep need
and triggers sleep drive. However, the molecular and cellular pathways by which sleep need …

Objective: Establish the dose-response relationship between increasing sleep durations in a
single night and recovery of neurobehavioral functions following chronic sleep restriction …

Introduction 3. Homeostatic regulation of sleep 3.1. EEG slow-wave activity: A physiological
indicator of nonREM sleep homeostasis 3.2. Interaction of homeostatic and circadian …

In recent years, theoretical models of the sleep and circadian system developed in
laboratory settings have been adapted to predict fatigue and, by inference, performance …