Simple Summary Recently, our understanding of PFK-2 isozymes, particularly with regards
to their roles in cancer, has developed significantly. This review aims to compile the most …

Background Cancer cells favor the use of less efficient glycolysis rather than mitochondrial
oxidative phosphorylation to metabolize glucose, even in oxygen-rich conditions, a distinct …

Cancer stem cells (CSCs) are a sub-population of tumour cells, which are responsible to
drive tumour growth, metastasis and therapy resistance. It has recently been proposed that …

Ovarian cancer is most deadly gynecologic malignancies worldwide. Chemotherapy is the
mainstay treatment for ovarian cancer. Despite the initial response is promising, frequent …

Reprogrammed metabolism and high energy demand are well-established properties of
cancer cells that enable tumor growth. Glycolysis is a primary metabolic pathway that …

Epithelial ovarian cancer, the most lethal gynecological malignancy, is diagnosed at
advanced stage, recurs and displays chemoresistance to standard chemotherapeutic …

Elevated metabolism is a key hallmark of multiple cancers, serving to fulfill high anabolic
demands. Ovarian cancer (OVCA) is the fifth leading cause of cancer deaths in women with …

Though used widely in cancer therapy, paclitaxel only elicits a response in a fraction of
patients. A strong determinant of paclitaxel tumor response is the state of microtubule …

The energetic demands of a cell are believed to increase during mitosis, but the rates of ATP
synthesis and consumption during mitosis have not been quantified. Here, we monitor …

Taxanes are microtubule-targeting drugs used as cytotoxic chemotherapy to treat most solid
tumors. The development of resistance to taxanes is a major cause of therapeutic failure and …