Design principles of microneedles for drug delivery and sampling applications

Z Le, J Yu, YJ Quek, B Bai, X Li, Y Shou, B Myint, C Xu… - Materials Today, 2023 - Elsevier
Microneedles technology is a powerful platform to achieve efficient transdermal delivery of
bioactive molecules for local or systemic therapies attributing to their minimally invasive …

Microneedle-mediated transdermal drug delivery for treating diverse skin diseases

D Yang, M Chen, Y Sun, Y Jin, C Lu, X Pan, G Quan… - Acta Biomaterialia, 2021 - Elsevier
Transdermal drug delivery is an attractive route for dermatological disease therapy because
it can directly target the lesion site on the skin, reduce adverse reactions associated with …

Microneedle-based natural polysaccharide for drug delivery systems (DDS): progress and challenges

F Damiri, N Kommineni, SO Ebhodaghe, R Bulusu… - Pharmaceuticals, 2022 - mdpi.com
In this focused progress review, the most widely accepted methods of transdermal drug
delivery are hypodermic needles, transdermal patches and topical creams. However …

3D-printed microneedle arrays for drug delivery

R Li, L Zhang, X Jiang, L Li, S Wu, X Yuan… - Journal of Controlled …, 2022 - Elsevier
Microneedle arrays provide an efficient tool for transdermal drug delivery in a minimally
invasive and painless manner, showing great potential applications in medicine. However, it …

Biodegradable microneedles fabricated with carbohydrates and proteins: Revolutionary approach for transdermal drug delivery

N Dabholkar, S Gorantla, T Waghule, VK Rapalli… - International Journal of …, 2021 - Elsevier
There has been a surge in the use of transdermal drug delivery systems (TDDS) for the past
few years. The market of TDDS is expected to reach USD 7.1 billion by 2023, from USD 5.7 …

Recent progress in PLGA-based microneedle-mediated transdermal drug and vaccine delivery

A Malek-Khatabi, MS Razavi, A Abdollahi… - Biomaterials …, 2023 - pubs.rsc.org
Microneedles (MNs) have recently been found to have applications in drug, vitamin, protein
and vaccine delivery. Polymeric MN arrays continue to attract increasing attention due to …

Microneedle arrays combined with nanomedicine approaches for transdermal delivery of therapeutics

V Alimardani, SS Abolmaali, G Yousefi… - Journal of Clinical …, 2021 - mdpi.com
Organic and inorganic nanoparticles (NPs) have shown promising outcomes in transdermal
drug delivery. NPs can not only enhance the skin penetration of small/biomacromolecule …

Polysaccharide-based transdermal drug delivery

J Li, H Xiang, Q Zhang, X Miao - Pharmaceuticals, 2022 - mdpi.com
Materials derived from natural plants and animals have great potential for transdermal drug
delivery. Polysaccharides are widely derived from marine, herbal, and microbial sources …

Microneedles for gene and drug delivery in skin cancer therapy

D Zhi, T Yang, T Zhang, M Yang, S Zhang… - Journal of Controlled …, 2021 - Elsevier
The success of skin cancer treatment is severely limited in the route of administration
because most genes and drugs cannot break through the excellent stratum corneum (SC) …

Hydrogel microneedle-assisted assay integrating aptamer probes and fluorescence detection for reagentless biomarker quantification

H Zheng, A GhavamiNejad, P GhavamiNejad… - ACS …, 2022 - ACS Publications
Analyzing interstitial fluid (ISF) via microneedle (MN) devices enables patient health
monitoring in a minimally invasive manner and in point-of-care settings. However, most MN …