Chalcones represent key structural motif in the plethora of biologically active molecules
including synthetic and natural products. Synthetic manipulations of chalcones or their …

A Hybrid drug which comprises the incorporation of two drug pharmacophores in one single
molecule are basically designed to interact with multiple targets or to amplify its effect …

Cancer cells are characterized by a higher rate of protein turnover and greater demand for
protein homeostasis compared to normal cells. In this scenario, the ubiquitin–proteasome …

Despite all the other cells that have the potential to prevent cancer development and
metastasis through tumour suppressor proteins, cancer cells can upregulate the ubiquitin …

Inhibition of deubiquitinase (DUB) activity is a promising strategy for cancer therapy.
VLX1570 is an inhibitor of proteasome DUB activity currently in clinical trials for relapsed …

The bis-benzylidine piperidone RA190 covalently binds to cysteine 88 of ubiquitin receptor
RPN13 in the 19S regulatory particle and inhibits proteasome function, triggering rapid …

There is an emerging paradigm shift in oncology that seeks to emphasize molecularly
targeted approaches for cancer prevention and therapy. Chalcones (1, 3-diphenyl-2-propen …

Interleukin-6 is one of the factors affecting sensitivity to cytotoxic agents. Therefore, the
current study was designed to investigate the role of IL-6 and IL6 receptors in the cytotoxic …

Abstract A solid-state photoluminescent 4-(Dimethylamino)-2ʹ-hydroxychalcone (Chalcone)
compound was designed and synthesized using the Claisen–Schmidt condensation …

We report the novel chalcone–benzoxaborole hybrids and their structure–activity
relationship against Trypanosoma brucei parasites. The 4-NH2 derivative 29 and 3-OMe …