NADPH-generating systems in bacteria and archaea

SK Spaans, RA Weusthuis, J Van Der Oost… - Frontiers in …, 2015 - frontiersin.org
Reduced nicotinamide adenine dinucleotide phosphate (NADPH) is an essential electron
donor in all organisms. It provides the reducing power that drives numerous anabolic …

Metabolic engineering of carbon and redox flow in the production of small organic acids

C Thakker, I Martínez, W Li, KY San… - Journal of Industrial …, 2015 - academic.oup.com
The review describes efforts toward metabolic engineering of production of organic acids.
One aspect of the strategy involves the generation of an appropriate amount and type of …

Cytosolic GAPDH as a redox-dependent regulator of energy metabolism

M Schneider, J Knuesting, O Birkholz, JJ Heinisch… - BMC plant biology, 2018 - Springer
Background Plant cytosolic NAD-dependent glyceraldehyde-3-phosphate dehydrogenase
(GapC) displays redox-dependent changes in its subcellular localizations and activity. Apart …

Engineering of Corynebacterium glutamicum with an NADPH-Generating Glycolytic Pathway for l-Lysine Production

S Takeno, R Murata, R Kobayashi… - Applied and …, 2010 - Am Soc Microbiol
ABSTRACT A sufficient supply of NADPH is a critical factor in l-lysine production by
Corynebacterium glutamicum. Endogenous NAD-dependent glyceraldehyde 3-phosphate …

Streptococcus pyogenes hijacks host glutathione for growth and innate immune evasion

S Brouwer, MG Jespersen, CLY Ong, DMP De Oliveira… - MBio, 2022 - Am Soc Microbiol
The nasopharynx and the skin are the major oxygen-rich anatomical sites for colonization by
the human pathogen Streptococcus pyogenes (group A Streptococcus [GAS]). To establish …

Engineering Escherichia coli for l-Threonine Hyperproduction Based on Multidimensional Optimization Strategies

Z Zhao, J You, X Shi, R Zhu, F Yang, M Xu… - Journal of Agricultural …, 2024 - ACS Publications
Exploring effective remodeling strategies to further improve the productivity of high-yield
strains is the goal of biomanufacturing. However, the lack of insight into host-specific …

Improving poly-3-hydroxybutyrate production in Escherichia coli by combining the increase in the NADPH pool and acetyl-CoA availability

S Centeno-Leija, G Huerta-Beristain… - Antonie Van …, 2014 - Springer
The biosynthesis of poly-3-hydroxybutyrate (P3HB), a biodegradable bio-plastic, requires
acetyl-CoA as precursor and NADPH as cofactor. Escherichia coli has been used as a …

Role of phosphate in the central metabolism of two lactic acid bacteria–a comparative systems biology approach

J Levering, MWJM Musters, M Bekker… - The FEBS …, 2012 - Wiley Online Library
Lactic acid‐producing bacteria survive in distinct environments, but show common metabolic
characteristics. Here we studied the dynamic interactions of the central metabolism in …

Characteristics of an Arabidopsis glyoxylate reductase: general biochemical properties and substrate specificity for the recombinant protein, and developmental …

GJ Hoover, OR Van Cauwenberghe, KE Breitkreuz… - Botany, 2007 - cdnsciencepub.com
Constitutive expression of an Arabidopsis thaliana (L.) Heynh cDNA (GenBank accession
No. AY044183) in a succinic semialdehyde (SSA) dehydrogenase-deficient yeast …

Structure-based functional analysis of a novel NADPH-producing glyceraldehyde-3-phosphate dehydrogenase from Corynebacterium glutamicum

HF Son, W Park, S Kim, IK Kim, KJ Kim - International Journal of Biological …, 2024 - Elsevier
Corynebacterium glutamicum is an industrial workhorse applied in the production of
valuable biochemicals. In the process of bio-based chemical production, improving cofactor …